engleski

Correlation of Histopathological and Serological Findings in Patients with Primary Sjṏgren Syndrome

Aim: Biopsy of small labial salivary gland (SLSG) is a gold standard in the diagnosis of pri-mary Sjögren’s syndrome (pSjS). The aim of this pilot study was to determine the corre-lation between serological and histopathological findings in patients with xerostomia and suspected primary Sjögren’s syndrome to determine if biopsy (SLSG) is a mandatory or accompanying diagnostic test for Sjoegren’s syndrome.Materials and Methods: The study included 29 subjects, of whom 28 women and 1 male (median age 62, range 29 to 81 years) who were referred to serological diagnostics (anti-SSA, anti-SSB) and in which small labial salivary glands biopsy was performed. Positive histopathological finding was considered to be a focal spot finding more then 1.Results: Positive histopathological findings had ten (34%) patients. Positive autoantibod-ies to anti-SSA had 38% of respondents, anti-SSB 28%, and combination of anti-SSA and anti-SSB 24%. In all subjects with positive serological findings of anti-SSA, anti-SSB and their combination high correlation with positive histopathological findings (73-100%) was found. High sensitivity has been demonstrated for anti-SSA (100%), for anti-SSB (83%) and less for combination anti-SSA and anti-SSB (77%).Conclusion: Primary Sjögren syndrome has been demonstrated in a third of subjects with high correlation of positive histopathological findings and autoantibodies (anti-SSA, an-ti-SSB, and combination anti-SSA and anti-SSB). In the case of a positive antibodies titer finding, histopathological diagnosis may be a accompanying diagnostic test rather than mandatory taking into account the high sensitivity of antibodies to SSA and SSB and in cases when biopsy is contraindicated.

Histopathological ; Serological Findings ; Primary Sjṏgren Syndrome

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