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Pregled bibliografske jedinice broj: 988447

Efficacy and safety of oral and inhalation commercial beta-glucan products: Systematic review of randomized controlled trials


Markovina, Nikolina; Banjari, Ines; Bučević Popović, Viljemka; Jeličić Kadić, Antonija; Puljak, Livia
Efficacy and safety of oral and inhalation commercial beta-glucan products: Systematic review of randomized controlled trials // Clinical nutrition (Edinburgh), 39 (2020), 1; 40-48 doi:10.1016/j.clnu.2019.01.003 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 988447 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Efficacy and safety of oral and inhalation commercial beta-glucan products: Systematic review of randomized controlled trials

Autori
Markovina, Nikolina ; Banjari, Ines ; Bučević Popović, Viljemka ; Jeličić Kadić, Antonija ; Puljak, Livia

Izvornik
Clinical nutrition (Edinburgh) (0261-5614) 39 (2020), 1; 40-48

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
beta-glucan ; systematic review ; evidence ; randomized controlled trial ; research waste

Sažetak
Background & aims Beta-glucans are advertised as biologically active compounds, with various health claims. We aimed to summarize results about efficacy and safety of commercial oral and inhalation beta-glucan products on human health from randomized controlled trials (RCTs). Methods We conducted systematic review of RCTs. We searched MEDLINE, CENTRAL and ClinicalTrials.gov. Any commercial product, any types of participants and any health-related outcomes were eligible. Two authors independently screened studies and extracted data. Cochrane risk of bias tool was used. This review did not have any extramural funding. Registration: PROSPERO record no. 42016043539. Results We included 30 RCTs that were conducted on healthy or ill participants. Most of the trials reported beneficial effect of beta- glucan, but among the 105 different outcome domains and measures that were used, only three could be considered clinically relevant, while others were various biomarkers and surrogate outcomes such as complete blood count. Included studies on average had 33 participants per study arm, high or unclear risk of bias of at least one domain, and only half of them reported data for safety. More than half of trials that reported source of funding indicated commercial sponsorship from producers of beta-glucan. Only five RCTs reported trial registration. Conclusions Commercial beta- glucan products were studied in a number of RCTs whose results can be considered only as preliminary, as they used small number of participants and surrogate outcomes. The quality of many studies was poor and further research and trials on bigger population should be performed before a final conclusion can be made.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita, Nutricionizam



POVEZANOST RADA


Ustanove:
Prehrambeno-tehnološki fakultet, Osijek,
KBC Split,
Prirodoslovno-matematički fakultet, Split,
Medicinski fakultet, Split

Citiraj ovu publikaciju

Markovina, Nikolina; Banjari, Ines; Bučević Popović, Viljemka; Jeličić Kadić, Antonija; Puljak, Livia
Efficacy and safety of oral and inhalation commercial beta-glucan products: Systematic review of randomized controlled trials // Clinical nutrition (Edinburgh), 39 (2020), 1; 40-48 doi:10.1016/j.clnu.2019.01.003 (međunarodna recenzija, članak, znanstveni)
Markovina, N., Banjari, I., Bučević Popović, V., Jeličić Kadić, A. & Puljak, L. (2020) Efficacy and safety of oral and inhalation commercial beta-glucan products: Systematic review of randomized controlled trials. Clinical nutrition (Edinburgh), 39 (1), 40-48 doi:10.1016/j.clnu.2019.01.003.
@article{article, year = {2020}, pages = {40-48}, DOI = {10.1016/j.clnu.2019.01.003}, keywords = {beta-glucan, systematic review, evidence, randomized controlled trial, research waste}, journal = {Clinical nutrition (Edinburgh)}, doi = {10.1016/j.clnu.2019.01.003}, volume = {39}, number = {1}, issn = {0261-5614}, title = {Efficacy and safety of oral and inhalation commercial beta-glucan products: Systematic review of randomized controlled trials}, keyword = {beta-glucan, systematic review, evidence, randomized controlled trial, research waste} }
@article{article, year = {2020}, pages = {40-48}, DOI = {10.1016/j.clnu.2019.01.003}, keywords = {beta-glucan, systematic review, evidence, randomized controlled trial, research waste}, journal = {Clinical nutrition (Edinburgh)}, doi = {10.1016/j.clnu.2019.01.003}, volume = {39}, number = {1}, issn = {0261-5614}, title = {Efficacy and safety of oral and inhalation commercial beta-glucan products: Systematic review of randomized controlled trials}, keyword = {beta-glucan, systematic review, evidence, randomized controlled trial, research waste} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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