Topological Biomarker of Alzheimer’s Disease (CROSBI ID 63295)
Prilog u knjizi | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Josef Golubić, Sanja
engleski
Topological Biomarker of Alzheimer’s Disease
For years, it has been assumed that the cerebral accumulation of pathologic protein forms is the main trigger of Alzheimer’s disease (AD) pathology ; however, recent studies revealed strong evidence that the alternations in synaptic activity precede and affect the homeostasis of amyloid-beta and tau, both of which aggregate during AD. Given that the neuropathological changes, characteristic for AD, start decades before the onset of the first symptoms when alternations become irreversible, it is crucial to find a biomarker that can detect the preclinical signs of disease, presumably synaptic dysfunction of specific cerebral areas. Here is presented a novel, a high potential neuroimaging biomarker that can detect the postsynaptic dysfunction of a specific neural substrate located in the medial prefrontal cortex (mPFC) during sensory gating processing of a simple auditory stimulus. The magnetoencephalography-based localization of mPFC gating activation has the potential not only to detect symptomatic AD but also to become a predictor of cognitive decline related to the pathophysiological processes of AD, both at the individual level. The strengths of proposed biomarker lie in the simplicity of using a binary value, i.e., activated or not activated a neural generator along with its potential to follow the evolution of the pathophysiological process of disease from the preclinical phase. The novel biomarker does not require estimation of uniform cutoff levels and standardization processes, the main problems of so far proposed biomarkers. Ability to individually detect AD pathology during putative preclinical and clinical stages, absolute noninvasiveness, and large effect size give this biomarker a high translation capacity and clinical potential.
Alzheimer’s disease, preclinical Alzheimer’s disease, Alzheimer’s disease biomarker, neuroimaging biomarker, auditory sensory gating, prefrontal cortex, magnetoencephalography
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
169-193.
objavljeno
10.5772/intechopen.76633
Podaci o knjizi
Biomarker - Indicator of Abnormal Physiological Process
Begum, Ghousia
London : Delhi: IntechOpen
2018.
978-1-78923-667-5
Trošak objave rada u otvorenom pristupu
Povezanost rada
Fizika, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)