engleski

Evolution of core peroxisomal proteins

There are a lot of unanswered questions about the evolutionary origin of the peroxisome. About ten years ago a phylogenetic analysis of peroxisomal proteome was conducted during which the minimal ancestral eukaryotic peroxisomal proteome was discovered. These days the larger amount of genomic data provides an ideal framework to analyze the origin of the ancestral peroxisome. To address this question phylogenetic trees for each protein from the proteome were reconstructed and complemented with predictions of subcellular localization and protein domain information to perform a detailed phylogenetic analysis. Peroxins Pex1, Pex2, Pex4 and Pex10 show common origin with the components of ERAD, Pex5 with components of anaphase promoting complex/cyclosome (APC/C) while Pex14 doesn’t have evolutionary relationship with any molecular system. Pxa1 and Pxa2 that are involved lipid transport show independent origin from its mitochondrial and cell membrane counterparts. Adding members from newly sequenced eukaryotic phyla and Asgard group didn’t change previously know phylogeny of catalase. Fox1 and Faa2 that are involved with peroxisomal β-oxidation show independent origin from the same process in mitochondria while Fox2 that catalyzes second step of β -oxidation is probably derived from mitochondria.

peroxisome, evolution, phylogenomics

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