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Pregled bibliografske jedinice broj: 986900

Second generation of primaquine ureas and bis-ureas as potential antimycobacterial agents


(Comenius University, Bratislava, Slovačka) Pavić, Kristina; Rajić, Zrinka; Michnová, Hana; Jampílek, Josef; Perković, Ivana; Zorc, Branka
Second generation of primaquine ureas and bis-ureas as potential antimycobacterial agents // Molecular diversity, 23 (2019), -; 657-667 doi:10.1007/s11030-018-9899-z (međunarodna recenzija, članak, znanstveni)


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Naslov
Second generation of primaquine ureas and bis-ureas as potential antimycobacterial agents

Autori
Pavić, Kristina ; Rajić, Zrinka ; Michnová, Hana ; Jampílek, Josef ; Perković, Ivana ; Zorc, Branka

Kolaboracija
Comenius University, Bratislava, Slovačka

Izvornik
Molecular diversity (1381-1991) 23 (2019); 657-667

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
primaquine ; urea ; aminoalcohol ; antimycobacterial activity

Sažetak
Here we describe design and synthesis of twelve novel compounds bearing primaquine motif and hydroxy- or halogenamine linked by an urea or bis-urea spacer. Preparation of ureas 3a-f started with the conversion of primaquine to benzotriazolide 2 and aminolysis of the later compound by 4-(2-aminoethyl)phenol or amino alcohols bearing fluorine atom, cycloalkyl or trifluoromethyl group under microwave irradiation. The four-step sequence leading to bis-ureas 6a-f included preparation of benzotriazolide 2 and two intermediates: semicarbazide 4 and benzotriazole bis-urea 5, which upon aminolysis with the same aminophenol or amino alcohols gave the title compounds. Antimycobacterial screening detected three active compounds against Mycobacterium marinum and M. tuberculosis, namely 3b, 3f and 6f, derived from cyclobutyl amino alcohol or amino phenol.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekt / tema
IP-09-2014-1501

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Zrinka Rajić (autor)

Avatar Url Ivana Perković (autor)

Avatar Url Branka Zorc (autor)

Avatar Url Kristina Pavić (autor)

Citiraj ovu publikaciju

(Comenius University, Bratislava, Slovačka) Pavić, Kristina; Rajić, Zrinka; Michnová, Hana; Jampílek, Josef; Perković, Ivana; Zorc, Branka
Second generation of primaquine ureas and bis-ureas as potential antimycobacterial agents // Molecular diversity, 23 (2019), -; 657-667 doi:10.1007/s11030-018-9899-z (međunarodna recenzija, članak, znanstveni)
(Comenius University, Bratislava, Slovačka) (Comenius University, Bratislava, Slovačka) Pavić, Kristina, Rajić, Z., Michnová, H., Jampílek, J., Perković, I. & Zorc, B. (2019) Second generation of primaquine ureas and bis-ureas as potential antimycobacterial agents. Molecular diversity, 23 (-), 657-667 doi:10.1007/s11030-018-9899-z.
@article{article, year = {2019}, pages = {657-667}, DOI = {10.1007/s11030-018-9899-z}, keywords = {primaquine, urea, aminoalcohol, antimycobacterial activity}, journal = {Molecular diversity}, doi = {10.1007/s11030-018-9899-z}, volume = {23}, number = {-}, issn = {1381-1991}, title = {Second generation of primaquine ureas and bis-ureas as potential antimycobacterial agents}, keyword = {primaquine, urea, aminoalcohol, antimycobacterial activity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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