engleski

Colposcopy significance in cervical premalignant lesions during pregnancy

Objective: The main aims of this study were (1) to present prevalence of cytologic abnormal Papanicolaou (Pap) smear, colposcopy results, prevalence of human papilloma virus (HPV) infection in pregnant women, and Pap smear and colposcopy results with histopathology findings 8 weeks after delivery ; and (2) the significance of colposcopy in pregnancy. Materials and Methods: This was a retrospective study from 2011 to 2012 in the Department of Gynecology and Obstetrics at the University Clinical Hospital Center “Sestre Milosrdnice, ” in Zagreb, Croatia. A total of 41 pregnant women were included in the study. Pap smear and colposcopy results during pregnancy and 8 weeks after delivery were analyzed along with HPV testing. Results: Pap smears prior to colposcopies showed high-grade squamous intraepithelial lesions (HSILs) in 73% of the women and low- grade squamous intraepithelial lesions (LSILs) in 22%. In 5%, atypical glandular cells (AGCs) seen on colposcopy showed G1 changes in 39% and G2 changes in 46%, and the findings were suspected of being invasive lesions in 5%. High-risk HPV was found in 44% and HPV 16 in 7%. HPV infection was not confirmed only in 5%. Eight weeks after delivery Pap smear showed regression of the disease in 63% and persistence of the disease in 34%. Normal Pap test results were found in 53%. Progression was noted in 3%. Furthermore, on colposcopy-guided biopsy 8 weeks after delivery performed in 15 patients showed LSIL in 13%, HSIL in 67%, and invasive carcinoma in 7%. Conclusions: Confirmations were found for high regression rates of Pap smear and colposcopy results after delivery and sufficiency of these tests for detection of cervical carcinoma. (J GYNECOL SURG 33:189)

colposcopy ; cervical premalignant lesions ; pregnancy

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