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Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing


Sikirić, Predrag; Ručman, Rudolf; Turković, Branko; Sever, Marko; Kliček, Robert; Radić, Božo; Drmić, Ivan Domagoj; Stupnišek, Mirjana; Mišić, Marija; Batelja Vuletić, Lovorka et al.
Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing // Current pharmaceutical design, 24 (2018), 18; 1990-2001 doi:10.2174/1381612824666180608101119 (međunarodna recenzija, članak, znanstveni)


Naslov
Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing

Autori
Sikirić, Predrag ; Ručman, Rudolf ; Turković, Branko ; Sever, Marko ; Kliček, Robert ; Radić, Božo ; Drmić, Ivan Domagoj ; Stupnišek, Mirjana ; Mišić, Marija ; Batelja Vuletić, Lovorka ; Horvat Pavlov, Katarina ; Barišić, Ivan ; Kokot, Antonio ; Peklić, Marina ; Strbe, Sanja ; Boban Blagaić, Alenka ; Tvrdeić, Ante ; Stančić-Rokotov, Dinko ; Vrčić, Hrvoje ; Starešinić, Mario ; Seiwerth, Sven

Izvornik
Current pharmaceutical design (1381-6128) 24 (2018), 18; 1990-2001

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Stable gastric pentadecapeptide BPC 157 ; control of blood vessels function ; cytoprotection ; endothelium protection ; organoprotection ; stomach cells protection

Sažetak
Years ago, we revealed a novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157, particular anti- ulcer peptide that heals different organs lesions when given as a therapy, native in human gastric juice while maintaining GI-tract mucosal integrity, already tested in trials (ulcerative colitis and now multiple sclerosis). The stomach cytoprotection is the most fundamental concept, stomach cell protection and endothelium protection are largely elaborated, but so far cell, protection and endothelium protection outside of the stomach were not implemented in the therapy. However, having managed these two points, stomach cell protection and endothelium protection, either one or together, even much more than standard cytoprotective agents do, BPC 157 employed large scale of its beneficial effects seen in various organs. Providing endothelium protection, BPC 157 was shown to prevent formation and reverse established thrombosis in anastomosed abdominal aorta as well as venous thrombosis after inferior caval vein occlusion, and attenuate bleeding prolongation and thrombocytopenia after amputation, without or with anticoagulants, or venous occlusion, and finally counteract effect of L-NAME and/or L-arginine. Now, with BPC 157 application, we reveal the third most important part of the cytoprotection concept: with the stomach cell and endothelium protection to recover mucosal integrity, BPC 157 as prototype cytoprotective agent should also control blood vessel function, depending upon injury, perforated defect or vessel obstruction. After a perforated injury (i.e., stomach), BPC 157 therapy activates blood vessels "running" towards defect. After obstruction (i.e., inferior caval vein), BPC 157 activates vessels "running" towards bypassing defect, collaterals functioning. Reestablished blood flow, and largely reversed injurious course may practically implement the cytoprotection concept.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
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  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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