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Pregled bibliografske jedinice broj: 985388

Interactions of macrolides with their biological targets


Novak, Predrag
Interactions of macrolides with their biological targets // Macrolides, Properties, Synthesis and Applications / Arsić, Biljana (ur.).
Berlin: De Gruyter, 2018. str. 63-77


Naslov
Interactions of macrolides with their biological targets

Autori
Novak, Predrag

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Macrolides, Properties, Synthesis and Applications

Urednik/ci
Arsić, Biljana

Izdavač
De Gruyter

Grad
Berlin

Godina
2018

Raspon stranica
63-77

ISBN
978-3-11-051502-2

Ključne riječi
Macrolides, interactions, binding epitopes

Sažetak
Macrolide antibiotics are effective and well-tolerated therapeutic agents for treating infectious diseases owing to their high efficacy and safety. Macrolides bind to the ribosomal 23S rRNA in domain V at or near the peptidyl transferase region and block the exit tunnel through which the nascent peptides leave the ribosome. A crucial step in the discovery of novel compounds for preventing resistance is to understand the principles of how macrolides interact with their macromolecular targets. Hence, by applying one-and two-dimensional NMR experiments it is possible to characterise the interactions of macrolides and ribosomes and to determine the reactive groups responsible for binding. The two most commonly used NMR techniques to study macrolide binding are transferred nuclear Overhauser effect spectroscopy (trNOESY) and saturation transfer difference (STD) NMR experiments.

Izvorni jezik
Engleski



POVEZANOST RADA


Autor s matičnim brojem:
Predrag Novak, (176404)