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Pregled bibliografske jedinice broj: 984730

Mechanochemical Catalytic Transfer Hydrogenation of Aromatic Nitro Derivatives


Portada, Tomislav; Margetić, Davor; Štrukil, Vjekoslav
Mechanochemical Catalytic Transfer Hydrogenation of Aromatic Nitro Derivatives // Molecules, 23 (2018), 12; 3163, 18 doi:10.3390/molecules23123163 (međunarodna recenzija, članak, znanstveni)


Naslov
Mechanochemical Catalytic Transfer Hydrogenation of Aromatic Nitro Derivatives

Autori
Portada, Tomislav ; Margetić, Davor ; Štrukil, Vjekoslav

Izvornik
Molecules (1420-3049) 23 (2018), 12; 3163, 18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Mechanochemistry ; catalytic transfer hydrogenation ; aromatic nitro derivatives ; ammonium formate ; aging ; ball milling ; synthesis

Sažetak
Mechanochemical ball milling catalytic transfer hydrogenation (CTH) of aromatic nitro compounds using readily available and cheap ammonium formate as the hydrogen source is demonstrated as a simple, facile and clean approach for the synthesis of substituted anilines and selected pharmaceutically relevant compounds. The scope of mechanochemical CTH is broad, as the reduction conditions tolerate various functionalities, for example nitro, amino, hydroxy, carbonyl, amide, urea, amino acid and heterocyclic. The presented methodology was also successfully integrated with other types of chemical reactions previously carried out mechanochemically, such as amide bond formation by coupling amines with acyl chlorides or anhydrides and click-type coupling reactions between amines and iso(thio)cyanates. In this way, we showed that active pharmaceutical ingredients Procainamide and Paracetamol could be synthesized from the respective nitro-precursors on milligram and gram scale in excellent isolated yields.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-9310 - Nekovalentne interakcije u dizajnu novih fotoosjetljivih molekula (Davor Margetić, )

Ustanove
Institut "Ruđer Bošković", Zagreb

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  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
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  • MEDLINE


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