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Pregled bibliografske jedinice broj: 984725

Mechanochemistry vs. solution growth: striking differences in bench stability of a cimetidine salt based on a synthetic method


Ayoub, Ghada; Štrukil, Vjekoslav; Fábián, László; Mottillo, Cristina; Bao, Huizhi; Murata, Yasujiro; Moores, Audrey; Margetić, Davor; Eckert-Maksić, Mirjana; Friščić, Tomislav
Mechanochemistry vs. solution growth: striking differences in bench stability of a cimetidine salt based on a synthetic method // Crystengcomm, 20 (2018), 7242-7247 doi:10.1039/C8CE01727A (međunarodna recenzija, članak, znanstveni)


Naslov
Mechanochemistry vs. solution growth: striking differences in bench stability of a cimetidine salt based on a synthetic method

Autori
Ayoub, Ghada ; Štrukil, Vjekoslav ; Fábián, László ; Mottillo, Cristina ; Bao, Huizhi ; Murata, Yasujiro ; Moores, Audrey ; Margetić, Davor ; Eckert-Maksić, Mirjana ; Friščić, Tomislav

Izvornik
Crystengcomm (1466-8033) 20 (2018); 7242-7247

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Mechanochemistry ; cimetidine ; solution growth

Sažetak
A mechanochemically prepared solvated salt of the archetypal blockbuster drug cimetidine exhibits significantly different bench stability to an analogous material made in solution. Samples obtained from solution are stable for weeks at room temperature and 45 °C, but mechanochemically made ones readily desolvate and convert to a new polymorph of non-solvated salt. While mechanochemistry becomes increasingly popular in synthesising drug solid forms, this work illustrates that it can have a profound effect on material stability.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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