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Bethesda thyroid categories and family history of thyroid disease

Objective:Thyroid cancer is the most common type of endocrine-related cancer worldwide. The aim of this article was to assess the relationship between thyroid diseases diagnosed by fine needle aspiration (FNA) and family history of thyroid disease. DesignThe study was conducted in a tertiary high- volume thyroid cancer centre. Fine needle aspiration (FNA) of a thyroid nodule detected on neck ultrasound for any reason was performed in all included patients. Patients A total of 10709 patients were included in the study. Measurements Correlation of cytological findings classified according to the Bethesda system and family history was calculated using Fisher's exact test. ResultsThere were 2580 (24.09%) patients with non-malignant thyroid diseases in the family and 198 (1.85%) patients who had a history of thyroid cancer in the family. A total of 2778 (25.94%) patients had positive family history of thyroid diseases, and 7931 (74.06%) patients had negative family history. In patients with papillary thyroid carcinoma in family history, the difference between those with benign (Bethesda 2) and malignant thyroid FNA diagnosis (Bethesda 6) was found to be statistically significant (P=.0432). ConclusionsFamily history plays a significant role in the development of thyroid cancer, and having first-degree relatives with not only medullary, but also papillary thyroid cancer strongly predicts the risk of developing the malignant thyroid disease. In contrast, benign thyroid disorders in family history do not lead to the development of thyroid cancer.

Bethesda system ; cytological finding ; familial thyroid cancer ; family history ; papillary thyroid cancer ; thyroid cancer ; thyroid disease

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