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Pregled bibliografske jedinice broj: 984406

NME/NM23/NDPK from unicellular eukaryotes to humans


Herak Bosnar, Maja; Perina, Drago; Harcet, Matija; Mikoč, Andreja; Bago, Ružica; Deželjin, Martina; Ćetković, Helena
NME/NM23/NDPK from unicellular eukaryotes to humans // FEBS3+ Conference: From Molecules to Living Systems : Final Programme & Book of Abstracts / Szuts, David ; Buday, Laszlo (ur.).
Veszprem: OOK-Press, 2018. str. 53-53 (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 984406 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
NME/NM23/NDPK from unicellular eukaryotes to humans

Autori
Herak Bosnar, Maja ; Perina, Drago ; Harcet, Matija ; Mikoč, Andreja ; Bago, Ružica ; Deželjin, Martina ; Ćetković, Helena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
FEBS3+ Conference: From Molecules to Living Systems : Final Programme & Book of Abstracts / Szuts, David ; Buday, Laszlo - Veszprem : OOK-Press, 2018, 53-53

ISBN
978-615-5270-47-5

Skup
FEBS3+conference From molecules to living systems

Mjesto i datum
Siofok, Mađarska, 02.-05. 2018

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Nm23 ; NME ; NDPK ; metastasis supressors

Sažetak
Nucleoside-diphosphate kinases (NME/Nm23/NDPK) are a family of evolutionary conserved enzymes present in all domains of life. The NDPKs transfer the terminal phosphate from a nucleoside triphosphate (mainly ATP) to all other NDPs. A huge interest for this enzyme started when it was discovered that a gene named nm23-H1 (non-metastatic clone 23, also known as NME1), responsible for suppression of metastasis in murine melanoma, is encoding one of the subunits of NDPK, NDPK A. The NME/Nm23/NDPK family members have been assigned a vast range of biological functions including metastasis suppression although the exact mechanism by which they execute their biological functions still remains to be unraveled. Numerous studies reported that proteins from evolutionary distinct organisms exhibit extraordinary similarity in their structures with their orthologs in mammals. Therefore, it is presumed that they have similar biochemical and biological functions which can, in consequence, serve as a new approach of studying human diseases. We performed a series of biochemical and biological tests which suggest that some of the NME genes/proteins in human are represented by a single ancestral type gene that already possesses many of the functions described in mammals. On the contrary, the NME genes that branched of very early in the evolutionary history seem to have changed significantly during metazoan evolution, and along did their protein function.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
098-0982913-2478
HRZZ-IP-2014-09-6400 - Istraživanje razvoja, diferencijacije i evolucije životinja kroz genomiku bazalnih metazoa (BAMGEN) (Vlahoviček, Kristian, HRZZ - 2014-09) ( POIROT)
MZOS-098-0982464-2513 - Uloga gena nm23 u karcinomu pločastog epitela usne šupljine (Herak-Bosnar, Maja, MZOS ) ( POIROT)
HRZZ-IP-2016-06-4021 - Struktura, funkcija i evolucija proteina Nme6/Nm23-H6 (Nemo6) (Herak-Bosnar, Maja, HRZZ - 2016-06) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb


Citiraj ovu publikaciju:

Herak Bosnar, Maja; Perina, Drago; Harcet, Matija; Mikoč, Andreja; Bago, Ružica; Deželjin, Martina; Ćetković, Helena
NME/NM23/NDPK from unicellular eukaryotes to humans // FEBS3+ Conference: From Molecules to Living Systems : Final Programme & Book of Abstracts / Szuts, David ; Buday, Laszlo (ur.).
Veszprem: OOK-Press, 2018. str. 53-53 (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)
Herak Bosnar, M., Perina, D., Harcet, M., Mikoč, A., Bago, R., Deželjin, M. & Ćetković, H. (2018) NME/NM23/NDPK from unicellular eukaryotes to humans. U: Szuts, D. & Buday, L. (ur.)FEBS3+ Conference: From Molecules to Living Systems : Final Programme & Book of Abstracts.
@article{article, author = {Herak Bosnar, Maja and Perina, Drago and Harcet, Matija and Miko\v{c}, Andreja and Bago, Ru\v{z}ica and De\v{z}eljin, Martina and \'{C}etkovi\'{c}, Helena}, year = {2018}, pages = {53-53}, keywords = {Nm23, NME, NDPK, metastasis supressors}, isbn = {978-615-5270-47-5}, title = {NME/NM23/NDPK from unicellular eukaryotes to humans}, keyword = {Nm23, NME, NDPK, metastasis supressors}, publisher = {OOK-Press}, publisherplace = {Siofok, Ma\djarska} }
@article{article, author = {Herak Bosnar, Maja and Perina, Drago and Harcet, Matija and Miko\v{c}, Andreja and Bago, Ru\v{z}ica and De\v{z}eljin, Martina and \'{C}etkovi\'{c}, Helena}, year = {2018}, pages = {53-53}, keywords = {Nm23, NME, NDPK, metastasis supressors}, isbn = {978-615-5270-47-5}, title = {NME/NM23/NDPK from unicellular eukaryotes to humans}, keyword = {Nm23, NME, NDPK, metastasis supressors}, publisher = {OOK-Press}, publisherplace = {Siofok, Ma\djarska} }




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