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Blood sample quality (CROSBI ID 260446)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Lippi, Giuseppe ; von Meyer, Alexander ; Cadamuro, Janne ; Šimundić, Ana-Maria Blood sample quality // Diagnosis, 1 (2018), 20180018, 1. doi: 10.1515/dx-2018-0018

Podaci o odgovornosti

Lippi, Giuseppe ; von Meyer, Alexander ; Cadamuro, Janne ; Šimundić, Ana-Maria

engleski

Blood sample quality

Several lines of evidence now confirm that the vast majority of errors in laboratory medicine occur in the extra-analytical phases of the total testing processing, especially in the preanalytical phase. Most importantly, the collection of unsuitable specimens for testing (either due to inappropriate volume or quality) is by far the most frequent source of all laboratory errors, thus calling for urgent strategies for improving blood sample quality and managing data potentially generated measuring unsuitable specimens. A comprehensive overview of scientific literature leads us to conclude that hemolyzed samples are the most frequent cause of specimen non-conformity in clinical laboratories (40–70%), followed by insufficient or inappropriate sample volume (10– 20%), biological samples collected in the wrong container (5–15%) and undue clotting (5–10%). Less frequent causes of impaired sample quality include contamination by infusion fluids (i.e. most often saline or glucose solutions), cross- contamination of blood tubes additives, inappropriate sample storage conditions or repeated freezing-thawing cycles. Therefore, this article is aimed to summarize the current evidence about the most frequent types of unsuitable blood samples, along with tentative recommendations on how to prevent or manage these preanalytical non-conformities.

blood samples ; errors ; hemolysis ; laboratory medicine ; quality

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Podaci o izdanju

1

2018.

20180018

1

objavljeno

2194-8011

2194-802X

10.1515/dx-2018-0018

Povezanost rada

Kliničke medicinske znanosti

Poveznice