Antiproliferative and pro‐apoptotic activities of wild asparagus (Asparagus acutifolius L.), black bryony (Tamus communis L.) and butcher's broom (Ruscus aculeatus L.) aqueous extracts against T24 and A549 cancer cell lines (CROSBI ID 260402)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Bilušić, Tea ; Šola, Ivana ; Rusak, Gordana ; Poljuha, Danijela ; Čikeš Čulić, Vedrana
engleski
Antiproliferative and pro‐apoptotic activities of wild asparagus (Asparagus acutifolius L.), black bryony (Tamus communis L.) and butcher's broom (Ruscus aculeatus L.) aqueous extracts against T24 and A549 cancer cell lines
The aim of this study was to determine the phenolic profile, antiproliferative, and pro‐apoptotic activities of Asparagus acutifolius, Tamus communis, and Ruscus aculeatus aqueous extracts against human bladder (T24) and lung cancer (A549) cell lines. Antiproliferative activity of the extracts at the concentration range from 0.5 to 4 mg/ml was measured by MTT test, after the incubation period of 4, 24, 48, or 72 hr. Pro‐apoptotic activity of selected plant extracts against T24 and A549 cells was analyzed by flow cytometry at the concentrations of 0.5, 1, and 2 mg/ml. The highest antiproliferative activity against both cancer cell lines was detected by T. communis aqueous extract. The highest pro‐apoptotic effect was achieved by A. acutifolius aqueous extract and its effect was similar against A549 and T24 cells.
A549, antiproliferative, apoptose, cancer cells, phenolic profile, T24, wild edible plants
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Podaci o izdanju
44 (3)
2019.
e12781
9
objavljeno
0145-8884
1745-4514
10.1111/jfbc.12781