engleski

Aortic stiffness in patients with COPD compared to two control groups of smokers and nonsmokers

ntroduction: Due to direct impact on survival, cardiovascular (CV) diseases are the most important comorbidities in COPD. Immediate assessment of arterial properties has been widely researched in last decade, as traditional risk factors for CV disease only indirectly suggest the atherosclerotic processes that herald future CV events. Arterial stiffness (AS) is generally accepted as a predictive factor for cardiovascular morbidity and mortality. Aims and objectives: To determine if patients with COPD, without documented comorbidities, have different determinants of AS compared to control groups of apparently healthy smokers and nonsmokers. Methods: Cross-sectional study in 2017 included 61 COPD patients, 83 non-COPD smokers and 65 nonCOPD nonsmokers, without comorbidities. After medical history and physical examination, oscillometric device and software were used to assess aortic pulse wave velocity (PWVao) noninvasively. COPD was evaluated by GOLD guidelines. Statistical analysis used Kolmogorov-Smirnov Test and One way ANOVA. Results: Patients with COPD achieved significantly (P<0.001) higher PWVao values (A=11.67 m/s, SD 2.72, 95%CI 10.97–12.36) than control group of non-COPD smokers (A=9.58 m/s, SD 1.61, 95%CI 9.23- 9.93) and group of non-COPD nonsmokers (A=9.09 m/s, SD 1.61, 95%CI 8.68-9.49). No difference in AS parameters was observed between two control groups of smokers and non-smokers (P=0.424). Conclusions: Patients with COPD have higher AS and ultimately elevated cardiovascular risk compared to non-COPD controls of smokers and nonsmokers. These results add to the pool of evidence that COPD, independently of smoking, contributes to pathogenesis of atherosclerosis.

COPD, Comorbidities, Extrapulmonary impact

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