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Pregled bibliografske jedinice broj: 983179

Clinical and laboratory characteristics of neuroinvasive viral zoonoses detected in continental Croatian regions, 2017-2018


Vilibic-Cavlek, Tatjana; Bogdanic, Maja; Savic, Vladimir; Tabain, Irena; Peric, Ljiljana; Sabadi, Dario; Potocnik-Hunjadi, Tanja; Miklausic, Bozana; Zember, Sanja; Santini, Marija et al.
Clinical and laboratory characteristics of neuroinvasive viral zoonoses detected in continental Croatian regions, 2017-2018 // International journal of infectious diseases, 79 (2019), 1; 123-123 doi:10.1016/j.ijid.2018.11.301 (međunarodna recenzija, ostalo)


Naslov
Clinical and laboratory characteristics of neuroinvasive viral zoonoses detected in continental Croatian regions, 2017-2018

Autori
Vilibic-Cavlek, Tatjana ; Bogdanic, Maja ; Savic, Vladimir ; Tabain, Irena ; Peric, Ljiljana ; Sabadi, Dario ; Potocnik-Hunjadi, Tanja ; Miklausic, Bozana ; Zember, Sanja ; Santini, Marija ; Kolaric-Sviben, Gordana ; Dvorski, Elizabeta ; Butigan, Tamara ; Jemersic, Lorena ; Prpic, Jelena ; Kolaric, Branko ; Balicevic, Marina ; Stevanovic, Vladimir ; Barbic, Ljubo ; Babic-Erceg, Andrea ; Listes, Eddy ; Madic, Josip ; Klobucar, Ana ; Savini, Giovanni

Izvornik
International journal of infectious diseases (1201-9712) 79 (2019), 1; 123-123

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, ostalo, ostalo

Ključne riječi
Neuroinvasive infections ; Arboviruses

Sažetak
Purpose: To analyze clinical and laboratory characteristics of neuroinvasive viral zoonoses detected in Croatia during 2017-2018. Methods & Materials: From April 2017 to June 2018, a total of 120 patients with neuroinvasive disease from continental Croatian regions were tested for the presence of neuroinvasive zoonotic viruses: tick-borne encephalitis virus (TBEV), West Nile virus (WNV), Usutu virus (USUV), Toscana virus (TOSV), Tahyna virus (TAHV) and lymphocytic choriomeningitis virus (LCMV). Cerebrospinal fluid (CSF) and urine samples were tested for the presence of viral RNA using a real-time RT- PCR and/or nested RT-PCR. Serological tests of serum/CSF samples (IgM/IgG antibodies, IgG avidity) were performed using ELISA (TBEV, WNV, USUV), IFA (TOSV, LCMV) and virus neutralization test (WNV). Results: Etiology was confirmed in 28/23.3% patients: TBEV in 20/16.7% and WNV in 8/6.6% patients by detection of IgM and IgG antibodies of low avidity and/or detection of viral RNA in CSF and urine. Majority of patients with TBEV infection were males (15/75.0%). Although infections were detected in all age groups, 15/75.0% patients were less than 60 years of age. The main clinical symptoms were headache (18/90.0%), weakness (18/90.0%), nausea (12/60.0%) and vomiting (8/40.0%). Fever >39 °C was noted in 16/80.0% patients. CSF leukocyte count ranged from 41-3520/mm3 with mononuclear cell predominance in 15/75.0% patients. All but one patient fully recovered. WNV infection was reported in 5/62.5% males and 3/37.5% females. All but one patient (7/87.5%) were older than 60 years. Majority of patients reported underlying diseases: hypertension (3/37.5%) and cerebrovascular disease (3/37.5%). The main clinical symptoms were headache (5/62.5%) and weakness (5/62.5%), while fever >39 °C was noted in 4/50.0% patients. CSF leukocyte count ranged from 56-1096/mm3 with mononuclear cell predominance in 4/50.0% patients. One patient died. USUV, TOSV, TAHV and LCMV infections were not detected during the tested period. Conclusion: TBEV infections were more common in patients less than 60 years of age, while WNV infections were most common in elderly. High fever was noted in 80.0% TBEV cases compared to 50.0% WNV cases. CSF pleocytosis was higher in TBEV infection.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2016-06-7456 - Prevalencija i molekularna epidemiologija emergentnih i reemergentnih neuroinvazivnih arbovirusnih infekcija na području Hrvatske (Tatjana Vilibić-Čavlek, HRZZ)

Ustanove
Hrvatski zavod za javno zdravstvo,
Hrvatski veterinarski institut, Zagreb,
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
Klinika za infektivne bolesti "Dr Fran Mihaljević",
Medicinski fakultet, Osijek

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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