engleski

POSSIBILITIES OF LIQUID BIOPSY IN CLINICAL PRACTICE

Liquid biopsy represents innovation in the fi eld of oncology diagnosis. It refers to non- invasive blood collection method with isolation of circulating tumor cells, cell-free DNA (with circulating tumor cell free DNA fraction), circulating exosomes or micro RNA. Although requires specifi c methods for isolation and analysis of targets of interest, liquid biopsy could be of benefi t in preoperative prediction od overall survival of patients with carcinoma, for monitoring of disease and progression, along with surveillance of therapy response and early recurrence of cancer. The review describes methods for liquid biopsy analysis, together with concerns and achievements in implementing liquid biopsy in clinical practice.

liquid biopsy, circulating tumor DNA - ctDNA, circulating tumor cells – CTCs, circulating microRNA – cmiRNA, exosomes, clinical practice

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