Position of Croatian Roma in the global ADME core markers’ variation landscape (CROSBI ID 672167)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Škarić-Jurić, Tatjana ; Smolej Narančić, Nina ; Janićijević, Branka ; Zajc Petranović, Matea ; Tomas, Željka ; Peričić Salihović, Marijana ;
engleski
Position of Croatian Roma in the global ADME core markers’ variation landscape
Introduction: The ADME (absorption, distribution, metabolism and excretion) genes' variation is markedly related to ethnicity and shows distinct geographic patterns. Generally, the knowledge on distribution of ADME genes in isolated populations is limited, particularly in the Roma, transnational minority population of Indian origin. The aim of this study is to determine the allele frequencies ADME “core list” markers and to compare them with world- wide data in order to elucidate the position of Roma in the global ADME genetic landscape. Methods: The 95 loci from 32 ADME genes were genotyped using KASP method in 440 Croatian Roma DNA samples. Data were analyzed using standard statistical population-genetics methods. Results: The analysis of genetic vs. geographic distances placed Croatian Roma among European populations but their proximity to South- Asian populations is also evident. Next, Roma show the outlying position on the global scale in minor allele frequencies of 12 loci: for 9 loci within 8 genes (rs1128503, rs1138272, rs1799853, rs1902023, rs3758581, rs8192709, rs10509681, rs12248560, rs34059508) they have the highest frequency while for three loci in three genes (rs28399433, rs28371725, rs4149117) have the lowest frequencies of the minor allele. Conclusion: The outlying positon in almost 13% of ADME core markers results from the specific genetic history of the Roma population. This finding may be helpful in developing personalized medicines’ protocols in drug therapies for this specific population. The research was funded by Croatian Science Foundation grant (HRZZ-IP-2014-09-4454) to MPS.
ADME, Roma, pharmacogenetics
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Podaci o prilogu
534-534.
2018.
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objavljeno
Podaci o matičnoj publikaciji
European journal of human genetics
van Ommen, Gert-Jan B
London : Delhi: Springer Nature
1018-4813
1476-5438
Podaci o skupu
European Human Genetics Conference
poster
16.06.2018-19.06.2018
Milano, Italija