Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 981103

Multicomponent Approach to a Library of N- Substituted γ-Lactams


Suć Sajko, Josipa; Ljoljić Bilić, Vanja; Kosalec, Ivan; Jerić, Ivanka
Multicomponent Approach to a Library of N- Substituted γ-Lactams // ACS Combinatorial Science, 21 (2019), 1; 28-34 doi:10.1021/acscombsci.8b00147 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 981103 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Multicomponent Approach to a Library of N- Substituted γ-Lactams

Autori
Suć Sajko, Josipa ; Ljoljić Bilić, Vanja ; Kosalec, Ivan ; Jerić, Ivanka

Izvornik
ACS Combinatorial Science (2156-8952) 21 (2019), 1; 28-34

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antibiofilm activity ; multicomponent reactions ; Ugi reaction ; γ-lactams

Sažetak
The γ-lactam motif is often found in naturally occurring compounds with diverse biological activities. We prepared a 28-member library of N-substituted γ-lactams following a single-pot, three-component Ugi reaction comprising bifunctional building block, l-glutamic acid methyl ester. The reaction tolerates structurally diverse carbonyl and isocyanide components providing a robust access to functionalized γ-lactams. Antimicrobial susceptibility testing, including agar well diffusion assay, serial microdilution broth assay, and antibiofilm activity testing, identified a potent compound with antibiofilm activity against Staphylococcus aureus ATCC 6538.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-3102 - Višekomponentne reakcije u sintezi peptidnih mimetika (MIMICRy) (Jerić, Ivanka, HRZZ - 2014-09) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Suć Sajko, Josipa; Ljoljić Bilić, Vanja; Kosalec, Ivan; Jerić, Ivanka
Multicomponent Approach to a Library of N- Substituted γ-Lactams // ACS Combinatorial Science, 21 (2019), 1; 28-34 doi:10.1021/acscombsci.8b00147 (međunarodna recenzija, članak, znanstveni)
Suć Sajko, J., Ljoljić Bilić, V., Kosalec, I. & Jerić, I. (2019) Multicomponent Approach to a Library of N- Substituted γ-Lactams. ACS Combinatorial Science, 21 (1), 28-34 doi:10.1021/acscombsci.8b00147.
@article{article, year = {2019}, pages = {28-34}, DOI = {10.1021/acscombsci.8b00147}, keywords = {antibiofilm activity, multicomponent reactions, Ugi reaction, γ-lactams}, journal = {ACS Combinatorial Science}, doi = {10.1021/acscombsci.8b00147}, volume = {21}, number = {1}, issn = {2156-8952}, title = {Multicomponent Approach to a Library of N- Substituted γ-Lactams}, keyword = {antibiofilm activity, multicomponent reactions, Ugi reaction, γ-lactams} }
@article{article, year = {2019}, pages = {28-34}, DOI = {10.1021/acscombsci.8b00147}, keywords = {antibiofilm activity, multicomponent reactions, Ugi reaction, γ-lactams}, journal = {ACS Combinatorial Science}, doi = {10.1021/acscombsci.8b00147}, volume = {21}, number = {1}, issn = {2156-8952}, title = {Multicomponent Approach to a Library of N- Substituted γ-Lactams}, keyword = {antibiofilm activity, multicomponent reactions, Ugi reaction, γ-lactams} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font