Napredna pretraga

Pregled bibliografske jedinice broj: 981043

Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC 157, L- NAME and L-arginine.


Drmic, Domagoj; Samara, Mariam; Vidovic, Tinka; Malekinusic, Dominik; Antunovic, Marko; Vrdoljak, Borna; Ruzman, Jelena; Perisa, Marija Milkovic; Pavlov, Katarina Horvat; Jeyakumar, Jerusha et al.
Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC 157, L- NAME and L-arginine. // World Journal of Gastroenterology, 24 (2018), 48; 5462-5476 doi:10.3748/wjg.v24.i48.5462 (međunarodna recenzija, članak, znanstveni)


Naslov
Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC 157, L- NAME and L-arginine.
(Counteraction of perforated cecum lesions in rats: effects of pentadecapeptide BPC 157, L- NAME and L-arginine)

Autori
Drmic, Domagoj ; Samara, Mariam ; Vidovic, Tinka ; Malekinusic, Dominik ; Antunovic, Marko ; Vrdoljak, Borna ; Ruzman, Jelena ; Perisa, Marija Milkovic ; Pavlov, Katarina Horvat ; Jeyakumar, Jerusha ; Seiwerth, Sven ; Sikiric, Predrag

Izvornik
World Journal of Gastroenterology (1007-9327) 24 (2018), 48; 5462-5476

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
BPC 157 ; L-NAME ; L-arginine ; Perforated cecum ; Rats ; Vessels

Sažetak
AIM: To study the counteraction of perforated cecum lesion using BPC 157 and nitric oxide (NO) system agents. METHODS: Alongside with the agents' application (after 1 min, medication (/kg, 10 mL/2 min bath/rat) includes: BPC 157 (10 μg), L-NAME (5 mg), L- arginine (100mg) alone or combined, and saline baths (controls)) on the rat perforate cecum injury, we continuously assessed the gross reappearance of the vessels (USB microcamera) quickly propagating toward the defect at the cecum surface, defect contraction, bleeding attenuation, MDA- and NO-levels in cecum tissue at 15 min, and severity of cecum lesions and adhesions at 1 and 7 d. RESULTS: Post-injury, during/after a saline bath, the number of vessels was significantly reduced, the defect was slightly narrowed, bleeding was significant and MDA-levels increased and NO- levels decreased. BPC 157 bath: the vessel presentation was markedly increased, the defect was noticeably narrowed, the bleeding time was shortened and MDA- and NO-levels remained normal. L-NAME: reduced vessel presentation but not more than the control, did not change defect and shortened bleeding. L-arginine: exhibited less vessel reduction, did not change the defect and prolonged bleeding. In combination, mutual counteraction occurred (L-NAME + L-arginine) or the presentation was similar to that of BPC 157 rats (BPC 157 + L-NAME ; BPC 157 + L-arginine ; BPC 157 + L-NAME + L-arginine), except the defect did not change. Thereby at day 1 and 7, saline, L-NAME, L-arginine and L-NAME + L- arginine failed (defect was still open and large adhesions present). CONCLUSION: The therapeutic effect was achieved with BPC 157 alone or in combination with L-NAME and L- arginine as it was able to consolidate the stimulating and inhibiting effects of the NO- system towards more effective healing recruiting vessels.

Izvorni jezik
Engleski



POVEZANOST RADA


Ustanove
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
  • Scopus
  • MEDLINE


Citati