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Pregled bibliografske jedinice broj: 980019

Cytotoxicity of gamma irradiated aflatoxin B1 and ochratoxin A


Domijan, Ana-Marija; Marjanović Čermak, Ana Marija; Vulić, Ana; Tartaro Bujak, Ivana; Pavičić, Ivan; Pleadin, Jelka; Markov, Ksenija; Mihaljević, Branka
Cytotoxicity of gamma irradiated aflatoxin B1 and ochratoxin A // Journal of environmental science and health. Part B: pesticides, food contaminants, and agricultural wastes, 54 (2019), 3; 155-162 doi:10.1080/03601234.2018.1536578 (međunarodna recenzija, članak, znanstveni)


Naslov
Cytotoxicity of gamma irradiated aflatoxin B1 and ochratoxin A

Autori
Domijan, Ana-Marija ; Marjanović Čermak, Ana Marija ; Vulić, Ana ; Tartaro Bujak, Ivana ; Pavičić, Ivan ; Pleadin, Jelka ; Markov, Ksenija ; Mihaljević, Branka

Izvornik
Journal of environmental science and health. Part B: pesticides, food contaminants, and agricultural wastes (0360-1234) 54 (2019), 3; 155-162

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cytotoxicity ; food safety ; gamma irradiation ; mycotoxins ; reduction

Sažetak
Toxicity of gamma irradiated mycotoxins aflatoxin B1 (AFB1) and ochratoxin A (OTA) was investigated in vitro. AFB1 and OTA stock solutions (50 mM, in methanol) were gamma irradiated (5 and 10 kGy) and non-irradiated and irradiated mycotoxins solutions were tested for cytotoxicity on Pk15, HepG2 and SH-SY5Y cell lines (MTT assay, 1–500 lM concentration range ; 24 h exposure). Degradation of mycotoxin molecules was examined by liquid chromatography tandem mass spectrometry (HPLC-MS/MS). AFB1 and OTA radiolytic products were less toxic than the parent mycotoxins to all of the tested cell lines. Gamma irradiation even at 5 kGy had effect on AFB1 and OTA molecules however, this effect was dependent on chemical structure of mycotoxin. Since gamma irradiation at low dose reduced initial level of both mycotoxins, and gamma irradiated mycotoxins had lower toxicity in comparison to non-irradiated mycotoxins, it can be concluded that gamma irradiation could be used as decontamination method.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Farmacija



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Hrvatski veterinarski institut, Zagreb,
Prehrambeno-biotehnološki fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Domijan, Ana-Marija; Marjanović Čermak, Ana Marija; Vulić, Ana; Tartaro Bujak, Ivana; Pavičić, Ivan; Pleadin, Jelka; Markov, Ksenija; Mihaljević, Branka
Cytotoxicity of gamma irradiated aflatoxin B1 and ochratoxin A // Journal of environmental science and health. Part B: pesticides, food contaminants, and agricultural wastes, 54 (2019), 3; 155-162 doi:10.1080/03601234.2018.1536578 (međunarodna recenzija, članak, znanstveni)
Domijan, A., Marjanović Čermak, A., Vulić, A., Tartaro Bujak, I., Pavičić, I., Pleadin, J., Markov, K. & Mihaljević, B. (2019) Cytotoxicity of gamma irradiated aflatoxin B1 and ochratoxin A. Journal of environmental science and health. Part B: pesticides, food contaminants, and agricultural wastes, 54 (3), 155-162 doi:10.1080/03601234.2018.1536578.
@article{article, year = {2019}, pages = {155-162}, DOI = {10.1080/03601234.2018.1536578}, keywords = {cytotoxicity, food safety, gamma irradiation, mycotoxins, reduction}, journal = {Journal of environmental science and health. Part B: pesticides, food contaminants, and agricultural wastes}, doi = {10.1080/03601234.2018.1536578}, volume = {54}, number = {3}, issn = {0360-1234}, title = {Cytotoxicity of gamma irradiated aflatoxin B1 and ochratoxin A}, keyword = {cytotoxicity, food safety, gamma irradiation, mycotoxins, reduction} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • AGRICOLA
  • ASFA: Aquatic Science and Fisheries Abstracts
  • CAB Abstracts


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