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Pregled bibliografske jedinice broj: 979700

Effects of melatonin and resveratrol on telomere dynamics in liver and kidneys in 1- and 2-year-old Wistar rats


Nanić, Lucia; Gerić, Marko; Gajski, Goran; Jurasović, Jasna; Karaica, Dean; Ljubojević, Marija; Micek, Vedran; Novak Jovanović, Ivana; Orct, Tatjana; Peraica, Maja et al.
Effects of melatonin and resveratrol on telomere dynamics in liver and kidneys in 1- and 2-year-old Wistar rats // Book of abstracts / Šarčević, Hrvoje ; Ugarković, Đurđica ; Vujaklija, Dušica ; Krešimir, Ivan S. ; Svetec Miklenić, Marina (ur.).
Zagreb: Croatian Genetic Society, 2018. str. 56-56 (poster, domaća recenzija, sažetak, znanstveni)


Naslov
Effects of melatonin and resveratrol on telomere dynamics in liver and kidneys in 1- and 2-year-old Wistar rats

Autori
Nanić, Lucia ; Gerić, Marko ; Gajski, Goran ; Jurasović, Jasna ; Karaica, Dean ; Ljubojević, Marija ; Micek, Vedran ; Novak Jovanović, Ivana ; Orct, Tatjana ; Peraica, Maja ; Rašić, Dubravka ; Vrhovac Madunić, Ivana ; Sabolić, Ivan ; Breljak, Davorka ; Rubelj, Ivica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts / Šarčević, Hrvoje ; Ugarković, Đurđica ; Vujaklija, Dušica ; Krešimir, Ivan S. ; Svetec Miklenić, Marina - Zagreb : Croatian Genetic Society, 2018, 56-56

ISBN
978-953-57128-1-7

Skup
4th Congress of Croatian Geneticists with International Participation

Mjesto i datum
Krk, Hrvatska, 26-29.09.2018.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Telomeres ; reactive oxigen species ; melatonin ; resveratrol ; rats

Sažetak
Telomeres are the main guardians of genome stability. During DNA replication, progressive shortening of telomeres takes place with each cell division. Critically short telomeres induce cell cycle arrest or apoptosis. Oxidative stress also plays an important role in telomere dynamics. Recent evidence highlights direct molecular connection between telomere attrition and mitochondrial dysfunction. Although reactive oxygen species (ROS) are normal products in intermediary metabolism, and are crucial for different intracellular signalling pathways, a disbalance resulting in ROS excess induces oxidative stress and accelerates telomere shortening. It is assumed that with ageing, production of ROS may be increased causing faster telomere shortening, and that both may be ameliorated by antioxidants. To test this hypothesis, we treated male and female Wistar rats for 9 or 21 months with melatonin and resveratrol and investigated their effect on telomere attrition rate in liver and kidney (various zones) tissues. Telomere length was assessed by Southern blotting of genomic DNA. The results in 1- and 2-year-old male and female rats showed an absence of significant differences in telomere length in the tissues from both organs after treatment with antioxidants compared to control (vehicle-treated) animals (N=4 per group). Based on obtained results, we did not observe beneficial properties of tested antioxidants towards age-dependent telomere shortening.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-1481 - Starosno-ovisna ekspresija membranskih prijenosnika u štakora (Ivan Sabolić, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb