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Pregled bibliografske jedinice broj: 979689

The role of metallothioneins in detoxification and oxidative stress


Andabak, Marija; Ivana, Živković; Paurević, Marija; Šrajer Gajdošik, Martina
The role of metallothioneins in detoxification and oxidative stress // ISC GREEN 2018 1st International Students' GREEN Conference, Book of Abstracts / Habuda-Stanić, Mirna (ur.).
Osijek: Sveučilište J. J. Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet Osijek, 2018. str. 146-146 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 979689 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The role of metallothioneins in detoxification and oxidative stress

Autori
Andabak, Marija ; Ivana, Živković ; Paurević, Marija ; Šrajer Gajdošik, Martina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
ISC GREEN 2018 1st International Students' GREEN Conference, Book of Abstracts / Habuda-Stanić, Mirna - Osijek : Sveučilište J. J. Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet Osijek, 2018, 146-146

ISBN
978-953-7005-56-6

Skup
1st International Students' GREEN Conference

Mjesto i datum
Osijek, Hrvatska, 17-18.05.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
metallothionein, toxic metals, free radicals, oxidative stress

Sažetak
Metallothineins (MTs) are low-molecular weight, metal-bindig proteins, rich in cysteine residues, present in virtually all living organisms. They are localized mainly in the cell cytoplasm, but can also be present in lysosomes, mitochondria and nuclei. MT molecule is a single polypeptide chain with more than one-third of amino acids being Cys residues, which can act as metal binding domains [1]. Therefore, the key role of MTs is maintaining the homeostasis of essential metals like Zn, but they also have high affinity for binding toxic metals like Cd, Hg and Pb. Due to their potent metal-binding and redox capabilities, important biological functions of MTs include heavy-metal detoxification, free radicals scavenging and protection of cells against the oxidative stress [1, 2]. Metal ions can induce MTs expression which can be used as a biomarker indicating environmental contamination with toxic metals [2]. MTs regulate levels of free radicals, shortly lived chemical particles containing one or more unpaired electrons generated by radiation and various biological processes. It was shown that MT can act as scavengers of superoxide and hydroxyl radicals or as Zn donor for enzymes participating in repairing processes and cell protection [3].

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Ustanove
Sveučilište u Osijeku - Odjel za kemiju

Citiraj ovu publikaciju

Andabak, Marija; Ivana, Živković; Paurević, Marija; Šrajer Gajdošik, Martina
The role of metallothioneins in detoxification and oxidative stress // ISC GREEN 2018 1st International Students' GREEN Conference, Book of Abstracts / Habuda-Stanić, Mirna (ur.).
Osijek: Sveučilište J. J. Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet Osijek, 2018. str. 146-146 (poster, međunarodna recenzija, sažetak, znanstveni)
Andabak, M., Ivana, Ž., Paurević, M. & Šrajer Gajdošik, M. (2018) The role of metallothioneins in detoxification and oxidative stress. U: Habuda-Stanić, M. (ur.)ISC GREEN 2018 1st International Students' GREEN Conference, Book of Abstracts.
@article{article, editor = {Habuda-Stani\'{c}, M.}, year = {2018}, pages = {146-146}, keywords = {metallothionein, toxic metals, free radicals, oxidative stress}, isbn = {978-953-7005-56-6}, title = {The role of metallothioneins in detoxification and oxidative stress}, keyword = {metallothionein, toxic metals, free radicals, oxidative stress}, publisher = {Sveu\v{c}ili\v{s}te J. J. Strossmayera u Osijeku, Prehrambeno-tehnolo\v{s}ki fakultet Osijek}, publisherplace = {Osijek, Hrvatska} }




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