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Pregled bibliografske jedinice broj: 978567

General anesthesia versus local anesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial 1999 to 2008.


GALA Trial Collaborative Group, Lewis, SC; Warlow, CP; Bodenham, AR; Colam, B; Rothwell, PM; Torgerson, D; i suradnici
General anesthesia versus local anesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial 1999 to 2008. // The Lancet, 372 (2008), 9656; 2132-2142 doi:10.1016/S0140-6736(08)61699-2 (međunarodna recenzija, članak, znanstveni)


Naslov
General anesthesia versus local anesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial 1999 to 2008.

Autori
GALA Trial Collaborative Group, Lewis, SC ; Warlow, CP ; Bodenham, AR ; Colam, B ; Rothwell, PM ; Torgerson, D ; i suradnici

Izvornik
The Lancet (0140-6736) 372 (2008), 9656; 2132-2142

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
General anaesthesia ; local anaesthesia ; carotid endarterectomy

Sažetak
Background The effect of carotid endarterectomy in lowering the risk of stroke ipsilateral to severe atherosclerotic carotid-artery stenosis is offset by complications during or soon after surgery. We compared surgery under general anaesthesia with that under local anaesthesia because prediction and avoidance of perioperative strokes might be easier under local anaesthesia than under general anaesthesia. Methods We undertook a parallel group, multicentre, randomised controlled trial of 3526 patients with symptomatic or asymptomatic carotid stenosis from 95 centres in 24 countries. Participants were randomly assigned to surgery under general (n=1753) or local (n=1773) anaesthesia between June, 1999 and October, 2007. The primary outcome was the proportion of patients with stroke (including retinal infarction), myocardial infarction, or death between randomisation and 30 days after surgery. Analysis was by intention to treat. The trial is registered with Current Control Trials number ISRCTN00525237. Findings A primary outcome occurred in 84 (4·8%) patients assigned to surgery under general anaesthesia and 80 (4·5%) of those assigned to surgery under local anaesthesia ; three events per 1000 treated were prevented with local anaesthesia (95% CI −11 to 17 ; risk ratio [RR] 0·94 [95% CI 0·70 to 1·27]). The two groups did not significantly differ for quality of life, length of hospital stay, or the primary outcome in the prespecified subgroups of age, contralateral carotid occlusion, and baseline surgical risk. Interpretation We have not shown a definite difference in outcomes between general and local anaesthesia for carotid surgery. The anaesthetist and surgeon, in consultation with the patient, should decide which anaesthetic technique to use on an individual basis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek,
Sveučilište J. J. Strossmayera u Osijeku

Autor s matičnim brojem:
Krunoslav Buljan, (357600)

Citiraj ovu publikaciju

GALA Trial Collaborative Group, Lewis, SC; Warlow, CP; Bodenham, AR; Colam, B; Rothwell, PM; Torgerson, D; i suradnici
General anesthesia versus local anesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial 1999 to 2008. // The Lancet, 372 (2008), 9656; 2132-2142 doi:10.1016/S0140-6736(08)61699-2 (međunarodna recenzija, članak, znanstveni)
GALA Trial Collaborative Group, Lewis, SC, Warlow, C., Bodenham, A., Colam, B., Rothwell, P., Torgerson, D. & i suradnici (2008) General anesthesia versus local anesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial 1999 to 2008.. The Lancet, 372 (9656), 2132-2142 doi:10.1016/S0140-6736(08)61699-2.
@article{article, year = {2008}, pages = {2132-2142}, DOI = {10.1016/S0140-6736(08)61699-2}, keywords = {general anaesthesia, local anaesthesia, carotid endarterectomy}, journal = {The Lancet}, doi = {10.1016/S0140-6736(08)61699-2}, volume = {372}, number = {9656}, issn = {0140-6736}, title = {General anesthesia versus local anesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial 1999 to 2008.}, keyword = {general anaesthesia, local anaesthesia, carotid endarterectomy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • MEDLINE


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