HDL subclasses and mortality in acute heart failure patients (CROSBI ID 258622)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Degoricija, Vesna ; Potočnjak, Ines ; Gastrager, Michaela ; Pregartner, Gudrun ; Berghold, Andrea ; Scharnagl, Hubert ; Stojaković, Tatjana ; Tiran, Beate ; Marsche, Gunther ; Frank, Saša
engleski
HDL subclasses and mortality in acute heart failure patients
The link between HDL subclasses and the prognosis of cardiovascular diseases remains controversial. We thus evaluated the prognostic value of the HDL subclasses 3 and 2 cholesterol (HDL3-C, HDL2-C) as well as of total HDL-C for 3-month mortality in acute heart failure (AHF) patients. The serum levels of HDL3-C and total HDL-C were determined by detergent-based homogeneous assay. HDL2-C was computed by the difference between total HDL-C and HDL3-C. Out of the 132 analyzed patients, 35 (26.5%) died within three months after onset of AHF. Univariate logistic regression analyses revealed a significant inverse association of HDL3-C (odds ratio (OR) 0.46 per 1-SD increase, 95% confidence interval (CI) 0.27–0.72, p = 0.001) with 3-month mortality, whereas concentrations of total HDL-C and HDL2-C showed no significant association. After adjustment for various laboratory and clinical parameters known to be associated with mortality in heart failure patients, HDL3-C concentrations remained significantly associated with 3-month mortality (OR 0.34 per 1-SD increase, 95% CI 0.15–0.74, p =0.010). We conclude that low admission serum levels of HDL3-C are associated with an increased 3-month mortality in AHF patients, whereas total HDL-C and HDL2-C showed no association. HDL3-C might thus be useful as a prognostic parameter in AHF.
HDL3 cholesterol ; HDL particles ; Homogeneous assays ; Outcome
This research was supported by the Austrian Science Foundation [P27166-B23 to SF], and the Jubilee Foundation of the Austrian National Bank [15858 to SF]. The funders had no roles in the design of the study, data collection, analysis, and interpretation, report writing or article submission.
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Podaci o izdanju
490 (March 2019)
2019.
81-87
objavljeno
0009-8981
1873-3492
10.1016/j.cca.2018.12.020
Povezanost rada
Kliničke medicinske znanosti