engleski

Clinical presentation of heart failure in female patients-results from CRO-HF Registry

Introduction: Heart failure (HF) could be different in a specific population. The aim of the study was to analyze the clinical presentation of HF in female patients according to results from CRO-HF Registry. Methods and Results: We analysed 2203 hospital HF patients (data based on CRO-HF Registry): 1175 (53.3%) males (m) and 1028 (46.7%) females (f) ; median age 76 y. One third patients suffered of acute HF. Preserved left ventricular function (LVEF = 50%) was recorded in 37.8% patients. Females had frequently preserved LVEF ( = 50%) (f- 49.3%, m-29.3%, p < 0.001) and males reduced LVEF ( < 50%) (m- 70.7%, f-50.7%). History of hypertension (AH) had 67.5% patients, diabetes 34.4%, myocardial infarction 22.7%, renal failure 19.2%, COPD 17.3%, stroke 16.5% and atrial fibrillation 53.7% patients. In males, comparative to females, important disease was COPD (m-19.7%, f-14.7%, p = 0.009), renal failure (m-23%, f- 14.8%, p < 0.001), diabetes (m-36.1%, 32.6%, P = 0.08), stroke (m-17.1%, f- 15.9%, P = 0.547) and smoking habit (m-14.8%, f-6.4%, p= < 0.001). The frequently precipitating factors of HF were: arrhytmiae (m-56.1, f-58.3), valvular diseases (m- 67.3%, f-67%) and infections (m- 18.7, f-20.4%). Important "trigger" in females was hypertension (f-58.7%, m-52.7%, P = 0.009), arrhytmiae (f- 58.3%, m-56.1%), infections (f- 20.4%, m- 18.7%), and acute coronary syndrome (ACS) in males (m- 22.1%, f-17%, P = 0.010). Females had often atrial arrhytmiae (f-92.2%, m-87.6, P = 0.010). Lower values of haemoglobin were recorded in 51.9% patients, higher creatinine had 46.8%, ALT 29.8%, cholesterol 32.7%, triglycerides 31.9%, uric acid 79.3%, and hyperglycaemia 99.8% patients. In females, we recorded higher values of ALT (f-33%, m-27%, P = 0.012, C = 0.066), cholesterol (f- 36.8%, m- 29.1%, P = 0.009), triglycerides (f- 36.1%, m- 28.3%, P = 0.014), uric acid (f-82.9%, m-76.4%, P =0.007), and males lower haemoglobin levels (m-58%, f-44.8%, p = 0.001). Hospital mortality was lower in males than in females (m- 12.6%, f- 14.4%). There were no significant differences in HF treatment according to gender. Conclusions: Clinical presentation of HF could be different in female patients, according to CRO-HF Registry. Females have frequently preserved LVEF, higher values of ALT, cholesterol, triglycerides, and uric acid, and males have lower values of LVEF and hemoglobin. Hypertension is an important "trigger" of HF in females and ACS in males. HF treatment should be adapted to clinical presentations of HF according to gender.

heart failure ; registry ; women ; female patients ; left ventricular ejection fraction ; CRO-HF registry ; gender differences ; in-hospital mortality

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