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Pregled bibliografske jedinice broj: 976261

Quinoline and ferrocene conjugates: Synthesis, computational study and biological evaluations


Maračić, Silvija; Lapić, Jasmina; Djaković, Senka; Opačak-Bernardi, Teuta; Glavaš-Obrovac, Ljubica; Vrček, Valerije; Raić-Malić, Silvana
Quinoline and ferrocene conjugates: Synthesis, computational study and biological evaluations // Applied organometallic chemistry, 33 (2019), 1; e4628-e4628 doi:10.1002/aoc.4628 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 976261 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Quinoline and ferrocene conjugates: Synthesis, computational study and biological evaluations

Autori
Maračić, Silvija ; Lapić, Jasmina ; Djaković, Senka ; Opačak-Bernardi, Teuta ; Glavaš-Obrovac, Ljubica ; Vrček, Valerije ; Raić-Malić, Silvana

Izvornik
Applied organometallic chemistry (0268-2605) 33 (2019), 1; E4628-e4628

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cytostatic effect, density functional theory, ferrocene, quinoline/quinolone, regioselectivity

Sažetak
Novel O‐alkylated quinoline and N‐alkylated 4‐quinolone derivatives attached to the ferrocene moiety through 4, 1‐ (7a–d, 8a–d and 12a–d) and 1, 4‐disubstituted (9a, 9b, 10a and 10b) 1, 2, 3‐triazole moiety were synthesized. The observed regioselectivity of O‐ vs. N‐alkylation was explored by the use of NMR and computational techniques. Among the N‐alkylated derivatives, the quinolone‐ferrocene conjugate 9a displayed marked activities against chronic myeloid leukemia in blast crisis (K562) and Burkitt lymphoma (Raji). The 6‐chloroquinolone‐ferrocene conjugate 12c, with selective inhibitory activity on Raji cells and no cytostatic effect on normal MDCK1 cells was highlighted as the most promising anticancer organometallic complex in a group of O‐alkylated quinolines.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Farmacija



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-1137 - Kvantno-kemijski dizajn, priprava i biološka svojstva organometalnih derivata nukleobaza (OrDeN) (Vrček, Valerije, HRZZ - 2016-06) ( POIROT)
HRZZ-IP-2013-11-5596 - SINTEZA I CITOSTATSKA ISPITIVANJA BIBLIOTEKE NOVIH DUŠIKOVIH HETEROCIKLA (SCIENcENTRY) (Raić-Malić, Silvana, HRZZ - 2013-11) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Prehrambeno-biotehnološki fakultet, Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište J. J. Strossmayera u Osijeku

Citiraj ovu publikaciju

Maračić, Silvija; Lapić, Jasmina; Djaković, Senka; Opačak-Bernardi, Teuta; Glavaš-Obrovac, Ljubica; Vrček, Valerije; Raić-Malić, Silvana
Quinoline and ferrocene conjugates: Synthesis, computational study and biological evaluations // Applied organometallic chemistry, 33 (2019), 1; e4628-e4628 doi:10.1002/aoc.4628 (međunarodna recenzija, članak, znanstveni)
Maračić, S., Lapić, J., Djaković, S., Opačak-Bernardi, T., Glavaš-Obrovac, L., Vrček, V. & Raić-Malić, S. (2019) Quinoline and ferrocene conjugates: Synthesis, computational study and biological evaluations. Applied organometallic chemistry, 33 (1), e4628-e4628 doi:10.1002/aoc.4628.
@article{article, year = {2019}, pages = {e4628-e4628}, DOI = {10.1002/aoc.4628}, keywords = {cytostatic effect, density functional theory, ferrocene, quinoline/quinolone, regioselectivity}, journal = {Applied organometallic chemistry}, doi = {10.1002/aoc.4628}, volume = {33}, number = {1}, issn = {0268-2605}, title = {Quinoline and ferrocene conjugates: Synthesis, computational study and biological evaluations}, keyword = {cytostatic effect, density functional theory, ferrocene, quinoline/quinolone, regioselectivity} }
@article{article, year = {2019}, pages = {e4628-e4628}, DOI = {10.1002/aoc.4628}, keywords = {cytostatic effect, density functional theory, ferrocene, quinoline/quinolone, regioselectivity}, journal = {Applied organometallic chemistry}, doi = {10.1002/aoc.4628}, volume = {33}, number = {1}, issn = {0268-2605}, title = {Quinoline and ferrocene conjugates: Synthesis, computational study and biological evaluations}, keyword = {cytostatic effect, density functional theory, ferrocene, quinoline/quinolone, regioselectivity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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