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Pregled bibliografske jedinice broj: 975907

Granulocytic sarcoma of the uterine cervix: a case report.


Mrčela, Milanka; Pajtler, Marija; Milojković; Miodrag
Granulocytic sarcoma of the uterine cervix: a case report. // Virchows Archiv, 459 (2011), 1; 243-243 (međunarodna recenzija, članak, stručni)


CROSBI ID: 975907 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Granulocytic sarcoma of the uterine cervix: a case report.

Autori
Mrčela, Milanka ; Pajtler, Marija ; Milojković ; Miodrag

Izvornik
Virchows Archiv (0945-6317) 459 (2011), 1; 243-243

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
uterine cervix ; granulocytic sarcoma ; acute myeloic leukemia

Sažetak
Background Granulocytic sarcoma (GS) of the uterine cervix is an unusual manifestation of acute myeloid leukemia (AML). Also known as chloroma, myeloid sarcoma and extramedullary myeloid sarcoma represents a solid tumor composed of immature white blood cells. Localized granulocytic sarcoma of the uterine cervix as a primary manifestation, preceding peripheral blood and bone marrow evidences of acute myeloic leukemia is very rare. Diagnosis of localized GS is difficult and is often confused with other neoplastic conditions. Methods We report a case of GS of the uterine cervix in a 46-years-old woman. Involvement of the cervix was the first manifestation of AML. The patient underwent colposcopy which was suspicious for malignancy. Colposcopically directed biopsy and cervical smear were taken. Results Cervical cytology smear stained with Papanicolaou stain contained numerous clusters of malignant cells that had monotonous appearance, with ovoid nuclei and coarse chromatin pattern. Nucleoli were present, not prominent, placed excentrically. The cytoplasm was scanty. Smear contained some squamous epithelial cells and plenty of erytrocytes. Cervical biopsy demonstrated diffuse infiltration of cervical tissue with uniform undifferentiated blastic tumor cells that were immunohistochemically stained positive for leukocyte common antigen (LCA), CD68, CD43, antimyeloperoxidase (MPO), lysozyme and partly for CD117 but were negative for CD20, CD3, CD4, CD7, CD8, CD45RO, CD 56, CD34, that was consistant with granulocytic sarcoma. Soon after the diagnosis, the disease progressed to AML and despite of aggresive chemotherapy the patient died six months later.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinički bolnički centar Osijek

Profili:

Avatar Url Marija Pajtler (autor)

Avatar Url Milanka Mrčela (autor)

Avatar Url Miodrag Milojković (autor)


Citiraj ovu publikaciju:

Mrčela, Milanka; Pajtler, Marija; Milojković; Miodrag
Granulocytic sarcoma of the uterine cervix: a case report. // Virchows Archiv, 459 (2011), 1; 243-243 (međunarodna recenzija, članak, stručni)
Mrčela, M., Pajtler, M., Milojković & Miodrag (2011) Granulocytic sarcoma of the uterine cervix: a case report.. Virchows Archiv, 459 (1), 243-243.
@article{article, year = {2011}, pages = {243-243}, keywords = {uterine cervix, granulocytic sarcoma, acute myeloic leukemia}, journal = {Virchows Archiv}, volume = {459}, number = {1}, issn = {0945-6317}, title = {Granulocytic sarcoma of the uterine cervix: a case report.}, keyword = {uterine cervix, granulocytic sarcoma, acute myeloic leukemia} }
@article{article, year = {2011}, pages = {243-243}, keywords = {uterine cervix, granulocytic sarcoma, acute myeloic leukemia}, journal = {Virchows Archiv}, volume = {459}, number = {1}, issn = {0945-6317}, title = {Granulocytic sarcoma of the uterine cervix: a case report.}, keyword = {uterine cervix, granulocytic sarcoma, acute myeloic leukemia} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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