engleski

Mixed germ cell - sex cord stromal tumor of the testis. A case report.

Introduction The mixed germ cell – sex cord stromal tumor of the testis is defined as neoplasm having neoplastic germ cells elements and neoplastic sex-cord stromal elements arranged in a diffuse pattern. Case report The case of a 45-year-old man with painless right sided testicular tumor is reported. Radiologic and laboratory investigations including serum alpha- fetoprotein (AFP) and human chorionic gonadotropin (HCG) showed no abnormalities. A right radical orchidectomy was performed. A histologic examination showed biphasic tumor which was composed of two different types of cells. The majority of the tumor consisted of quite unifom predominantly spindle cells, which were immunohistochemically positive for vimentin and S-100 protein and focally for α- inhibin. The second cell type were large cells with abundant clear cytoplasm arranged in a small clusters at the periphery of the tumor. These cells showed no reactivity for immunostains mentioned above neither for cytokeratines MNF 116 and 7, AFP, HCG and PLAP. Conclusion As any rare neoplasm the mixed germ cell – sex cord stromal tumor of the testis makes a huge diagnostic problem. Clinical and biological behavior of this type of testicular neoplasm is not jet completely discovered.

testis ; germ cell - sex cord stromal tumor

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