engleski

De Novo Chromosome Breakage

AIM: Chromosomal breaks occur spontaneously or are induced by ionizing radiation and chemotherapeutic drugs. They are also present in certain types of cancer or are caused by some viruses. Different types of chromosome damages occur de novo in the long-term progeny of irradiated cells. Tumours undergo gains and losses of entire chromosomes, as well as segmental defects caused by chromosome breaks. Investigations show that the expression of early genes of some viruses in host cells induces chromosomal damage inhibiting DNA synthesis and cell division. The most common aberrations were chromosome fragmentation, translocations, centromeric and chromosomal/chromatid breakage and fractures whose formation is considered to be random with no specific sites on chromosomes. MATERIAL AND METHODS: We present a case of de novo chromosomal aberrations and translocations in young men with sterility problems. For patient and his wife we used the short culture of peripheral blood lymphocyte with standard GTG banding method and indication for karyotyping young couple is sterility. Chromosome analysis showed aberration in 3 metaphases as follows: centromeric breakage of chromosome 9, complete deletion of short arm of chromosome 9 del(9p) centromeric breakage of chromosome 1 and long arm deletion of chromosome 9 del (9q31) with a translocation between chromosome 5 and 11 /t(5 ; 11)/. To exclude problems during harvesting we repeated karyotyping. Two months later we repeated karyotyping and found normal male karyotype (46, XY) in all analyzed cells. We were informed that during the first analysis the patient had an acute infection of the herpes zoster virus. CONCLUSION: Oncogenic viruses like adenovirus, herpes simplex, herpes zoster, EBV, HCMV, hepatitis B, mumps, rubella, poliovirus and papillomavirus, have been found to cause non- random, site-specific chromosomal damage. This case shows nonspecific aberration in herpes zoster virus infection.

de novo chromosomal aberrations, herpes zoster virus

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