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izvor podataka: crosbi

Monitoring of sulfonamides, macrolides and other pharmaceuticals in surface waters in Croatia (CROSBI ID 670817)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Žuntar, Irena ; Krivohlavek, Adela ; Ivešić, Martina ; Tolic, Sonja ; Šikic, Sandra ; Musić, Valerija ; Pavlić, Ivan ; Bursik Andrea ; Galić, Nives Monitoring of sulfonamides, macrolides and other pharmaceuticals in surface waters in Croatia // Pharmaceutical Regulatory Affairs: Open Access. Frankfurt, 2018. str. 73-73 doi: 10.4172/2167-7689-C1-031

Podaci o odgovornosti

Žuntar, Irena ; Krivohlavek, Adela ; Ivešić, Martina ; Tolic, Sonja ; Šikic, Sandra ; Musić, Valerija ; Pavlić, Ivan ; Bursik Andrea ; Galić, Nives

engleski

Monitoring of sulfonamides, macrolides and other pharmaceuticals in surface waters in Croatia

Sulfonamides, macrolides, torasemide, fumagillin and chloramphenicol were simultaneously analyzed in surface water samples by using solid-phase extraction (SPE) and reversed-phase (RP) liquid chromatography- electrospray tandem mass spectrometry (LC-ESI- MS/MS). In the pre- concentration and clean-up process, the pH value of samples and volume of the solvent for extraction of analytes from cartridge were optimized. Extraction recoveries were high with values in the range from 62 to 115%. Limits of quantification (LoQ) were in the range from 0.02 µg/L–0.2 µg/L. Repeatability of the method was evaluated at LoQ and expressed as relative standard deviation (RSD). Calculated RSDs were low with values in the range from 2.4 to 14.5%. The method was successfully applied for analysis of the real samples of surface waters. Samples were collected along the rivers in Croatia on 19 sampling sites in Danube and Adriatic catchment areas in 2013, and another 20 places in 2014. Altogether, 20 target compounds were analyzed in 362 water samples and detected in 24 samples in the range, 0.02–5.3 µg/L or in 6.6% of samples. The most frequent and highest concentrations were detected for macrolide antibiotics. This is the first attempt of monitoring of antibiotics in surface waters in Croatia.

sulfonamides ; macrolides ; pharmaceuticals ; surface water

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Podaci o prilogu

73-73.

2018.

objavljeno

10.4172/2167-7689-C1-031

Podaci o matičnoj publikaciji

Pharmaceutical Regulatory Affairs: Open Access

Frankfurt:

2167-7689

Podaci o skupu

15th Annual European Pharma Congress

poster

07.05.2018-09.05.2018

Frankfurt na Majni, Njemačka

Povezanost rada

Farmacija, Javno zdravstvo i zdravstvena zaštita, Kemija

Poveznice