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Pregled bibliografske jedinice broj: 973783

Genome rearrangements in radiation-resistant bacteria


Repar, Jelena; Supek, Fran; Klanjscek, Tin; Warnecke, Tobias; Zahradka, Ksenija; Zahradka, Davor
Genome rearrangements in radiation-resistant bacteria // 4th Congress of Croatian Geneticists with international participation - Book of Abstracts / Šarčević, Hrvoje ; Ugarković, Đurđica ; Vujaklija, Dušica ; Svetec, Ivan Krešimir ; Svetec Miklenić, Marina (ur.).
Zagreb: Croatian Genetic Society, 2018. str. 24-24 (predavanje, recenziran, sažetak, znanstveni)


Naslov
Genome rearrangements in radiation-resistant bacteria

Autori
Repar, Jelena ; Supek, Fran ; Klanjscek, Tin ; Warnecke, Tobias ; Zahradka, Ksenija ; Zahradka, Davor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
4th Congress of Croatian Geneticists with international participation - Book of Abstracts / Šarčević, Hrvoje ; Ugarković, Đurđica ; Vujaklija, Dušica ; Svetec, Ivan Krešimir ; Svetec Miklenić, Marina - Zagreb : Croatian Genetic Society, 2018, 24-24

ISBN
978-953-57128-1-7

Skup
4th Congress of Croatian Geneticists with International Participation

Mjesto i datum
Krk, Hrvatska, 26-29.09.2018

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Recenziran

Ključne riječi
Genome rearrangments, gene order, radiation-resistant species, DNA double-strand breaks

Sažetak
A number of bacterial, archaeal, and eukaryotic species are known for their resistance to ionizing radiation. One of the challenges these species face is a potent environmental source of DNA double-strand breaks, potential drivers of genome structure evolution. Efficient and accurate DNA double-strand break repair systems have been demonstrated in several unrelated radiation- resistant species and are putative adaptations to the DNA damaging environment. Such adaptations are expected to compensate for the genome- destabilizing effect of environmental DNA damage and may be expected to result in a more conserved gene order in radiation-resistant species. However, we show that rates of genome rearrangements, measured as loss of gene order conservation with time, are higher in radiation- resistant species in multiple, phylogenetically independent groups of bacteria. Furthermore, we explore whether detected high rearrangement rates in radiation-resistant species constitute a survival strategy or are a passive consequence of environmental DNA damage.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-2978 - Rekombinacija, popravak DNA i očuvanje integriteta genoma: novi putevi (Davor Zahradka, )

Ustanove
Institut "Ruđer Bošković", Zagreb