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Pregled bibliografske jedinice broj: 973581

Fas receptor induces apoptosis of synovial bone and cartilage progenitor populations and promotes bone loss in antigen-induced arthritis


Lazić Mosler, Elvira; Lukač, Nina; Flegar, Darja; Fadljević, Martina; Radanović, Igor; Cvija, Hrvoje; Kelava, Tomislav; Ivčević, Sanja; Šućur, Alan; Markotić, Antonio et al.
Fas receptor induces apoptosis of synovial bone and cartilage progenitor populations and promotes bone loss in antigen-induced arthritis // The FASEB journal, 33 (2018), 10.1096/fj.201801426R, 13 doi:10.1096/fj.201801426R (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 973581 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Fas receptor induces apoptosis of synovial bone and cartilage progenitor populations and promotes bone loss in antigen-induced arthritis

Autori
Lazić Mosler, Elvira ; Lukač, Nina ; Flegar, Darja ; Fadljević, Martina ; Radanović, Igor ; Cvija, Hrvoje ; Kelava, Tomislav ; Ivčević, Sanja ; Šućur, Alan ; Markotić, Antonio ; Katavić, Vedran ; Marušić, Ana ; Grčević, Danka ; Kovačić, Nataša

Izvornik
The FASEB journal (0892-6638) 33 (2018); 10.1096/fj.201801426R, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Fas, osteoprogenitors, arthritis, inflammation induced bone loss, cartilage progenitors

Sažetak
Rheumatoid arthritis (RA) is inflammatory joint disease that eventually leads to permanent bone and cartilage destruction. Fas has already been established as the regulator of inflammation in RA, but its role in bone formation under arthritic conditions is not completely defined. The aim of this study was to assess the effect of Fas inactivation on the bone damage during murine antigen-induced arthritis. Subchondral bone of wild-type (WT) and Fas-knockout (Fas−/ −) mice was evaluated by histomorphometry and microcomputerized tomography. Proportions of synovial bone and cartilage progenitors were assessed by flow cytometry. Synovial bone and cartilage progenitors were purified by fluorescence-activated cell sorting and expression of Fas and Fas-induced apoptosis were analyzed in vitro. Results showed that Fas−/− mice developed attenuated arthritis characterized by preserved epiphyseal bone and cartilage. A proportion of the earliest CD200+ bone and cartilage progenitors was reduced in WT mice with arthritis and was unaltered in Fas−/− mice. During osteoblastic differentiation in vitro, CD200+ cells express the highest levels of Fas and are removed by Fas ligation. These results suggest that Fas- induced apoptosis of early CD200+ osteoprogenitor population represents potential mechanism underlying the impaired bone formation in arthritis, so their preservation may represent the bone-protective mechanism during arthritis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb

doi

Citiraj ovu publikaciju

Lazić Mosler, Elvira; Lukač, Nina; Flegar, Darja; Fadljević, Martina; Radanović, Igor; Cvija, Hrvoje; Kelava, Tomislav; Ivčević, Sanja; Šućur, Alan; Markotić, Antonio et al.
Fas receptor induces apoptosis of synovial bone and cartilage progenitor populations and promotes bone loss in antigen-induced arthritis // The FASEB journal, 33 (2018), 10.1096/fj.201801426R, 13 doi:10.1096/fj.201801426R (međunarodna recenzija, članak, znanstveni)
Lazić Mosler, E., Lukač, N., Flegar, D., Fadljević, M., Radanović, I., Cvija, H., Kelava, T., Ivčević, S., Šućur, A. & Markotić, A. (2018) Fas receptor induces apoptosis of synovial bone and cartilage progenitor populations and promotes bone loss in antigen-induced arthritis. The FASEB journal, 33, 10.1096/fj.201801426R, 13 doi:10.1096/fj.201801426R.
@article{article, year = {2018}, pages = {13}, DOI = {10.1096/fj.201801426R}, chapter = {10.1096/fj.201801426R}, keywords = {Fas, osteoprogenitors, arthritis, inflammation induced bone loss, cartilage progenitors}, journal = {The FASEB journal}, doi = {10.1096/fj.201801426R}, volume = {33}, issn = {0892-6638}, title = {Fas receptor induces apoptosis of synovial bone and cartilage progenitor populations and promotes bone loss in antigen-induced arthritis}, keyword = {Fas, osteoprogenitors, arthritis, inflammation induced bone loss, cartilage progenitors}, chapternumber = {10.1096/fj.201801426R} }
@article{article, year = {2018}, pages = {13}, DOI = {10.1096/fj.201801426R}, chapter = {10.1096/fj.201801426R}, keywords = {Fas, osteoprogenitors, arthritis, inflammation induced bone loss, cartilage progenitors}, journal = {The FASEB journal}, doi = {10.1096/fj.201801426R}, volume = {33}, issn = {0892-6638}, title = {Fas receptor induces apoptosis of synovial bone and cartilage progenitor populations and promotes bone loss in antigen-induced arthritis}, keyword = {Fas, osteoprogenitors, arthritis, inflammation induced bone loss, cartilage progenitors}, chapternumber = {10.1096/fj.201801426R} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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