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Pregled bibliografske jedinice broj: 973123

Arterial stiffness as a measure of cardiovascular risk in obese adolescents and adolescents with diabetes type 1


Putarek, Kresimir; Banfic, Ljiljana; Pasalic, Marijan; Krnic, Nevena; Spehar Uroic, Anita; Rojnic Putarek, Natasa
Arterial stiffness as a measure of cardiovascular risk in obese adolescents and adolescents with diabetes type 1 // Journal of Pediatric Endocrinology and Metabolism, 31 (2018), 12; 1315-1323 doi:10.1515/jpem-2018-0137 (međunarodna recenzija, članak, znanstveni)


Naslov
Arterial stiffness as a measure of cardiovascular risk in obese adolescents and adolescents with diabetes type 1

Autori
Putarek, Kresimir ; Banfic, Ljiljana ; Pasalic, Marijan ; Krnic, Nevena ; Spehar Uroic, Anita ; Rojnic Putarek, Natasa

Izvornik
Journal of Pediatric Endocrinology and Metabolism (0334-018X) 31 (2018), 12; 1315-1323

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Adolescenti ; krutost arterijske stjenke ; dijabetes ; pretilost
(Adolescents ; arterial stiffness ; cardiovascular risk ; diabetes type 1 ; obesity.)

Sažetak
Background: Cardiovascular disease (CVD) is the end result of vascular aging and atherosclerosis, having its origins in childhood. The aim of our study was to compare arterial stiffness (AS) and intima-media thickness (IMT) as markers of an early vascular damage between obese adolescents, adolescents with diabetes type 1 (T1D) and lean control subjects. Methods: We analyzed AS and IMT in 68 obese adolescents (13.27 ± 2.31 years), 42 adolescents with T1D (14.95 ± 2.35 years) lasting over 5 years and 38 controls (15.02 ± 1.94 years). AS (measured by pulse wave velocity [PWV], arterial compliance [AC] and β-stiffness) and IMT were assessed using an e-tracking ultrasound method. Results: A significant difference between the groups was found for AC (p = 0.022) and PWV (p = 0.010), with the lowest compliance and higher velocities in T1D patients. When corrected for age, the difference in AC among the groups did not reach a statistical difference (p = 0.059). Correlation analysis in the obese adolescents showed lower AC in females (p = 0.041), with higher systolic blood pressure (SBP) (p = 0.032). In T1D adolescents, disease duration was the strongest determinant of AS (AC p = 0.028, β p = 0.029 and PWV p = 0.003), followed by body mass index (BMI ; PWV p = 0.008 ; β p = 0.033), SBP (AC p < 0.001 ; PWV p = 0.023), diastolic BP (AC p = 0.049 ; PWV p = 0.048) and HbA1c (PWV p = 0.048). No significant correlations were found for AS measures or IMT with sex, age, BMI, Tanner stage or BP levels in controls. Conclusions: Early vascular damage is more pronounced in T1D adolescents than in obese or lean adolescents, which may emphasize the impact of hyperglycemia as a major threat for cardiovascular health.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
  • Scopus
  • MEDLINE


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