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Pregled bibliografske jedinice broj: 972938

Sodium-glucose cotransporters: new targets of cancer therapy?


Vrhovac Madunić, Ivana; Madunić, Josip; Breljak, Davorka; Karaica, Dean; Sabolić, Ivan
Sodium-glucose cotransporters: new targets of cancer therapy? // Arhiv za higijenu rada i toksikologiju, 69 (2018), 4; 278-284 doi:10.2478/aiht-2018-69-3204 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
Sodium-glucose cotransporters: new targets of cancer therapy?

Autori
Vrhovac Madunić, Ivana ; Madunić, Josip ; Breljak, Davorka ; Karaica, Dean ; Sabolić, Ivan

Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 69 (2018), 4; 278-284

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
brain cancer ; Na+-dependent glucose transporters ; pancreatic cancer ; positron emission tomography ; prostate cancer ; SGLT inhibitors

Sažetak
Glucose, the key source of metabolic energy, is imported into cells by two categories of transporters: 1) facilitative glucose transporters (GLUTs) and 2) secondary active sodium- glucose cotransporters (SGLTs). Cancer cells have an increased demand for glucose uptake and utilisation compared to normal cells. Previous studies have demonstrated the overexpression of GLUTs, mainly GLUT1, in many cancer types. As the current standard positron emission tomography (PET) tracer 2- deoxy-2-(18 F)fluoro-D-glucose (2-FDG) for imaging tumour cells via GLUT1 lacks in sensitivity and specificity, it may soon be replaced by the newly designed, highly sensitive and specific SGLT tracer α-methyl-4-(F- 18)fluoro-4- deoxy-D- glucopyranoside (Me-4FDG) in clinical detection and tumour staging. This tracer has recently demonstrated the functional activity of SGLT in pancreatic, prostate, and brain cancers. The mRNA and protein expression of SGLTs have also been reported in colon/colorectal, lung, ovarian, head, neck, and oral squamous carcinomas. So far, SGLTs have been poorly investigated in cancer, and their protein expression and localisation are often controversial due to a lack of specific SGLT antibodies. In this review, we describe current knowledge concerning SGLT1 and SGLT2 (over)expression in various cancer types. The findings of SGLTs in malignant cells may help in developing novel cancer therapies with SGLT2 or SGLT1/SGLT2 inhibitors already used in diabetes mellitus treatment.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Citiraj ovu publikaciju

Vrhovac Madunić, Ivana; Madunić, Josip; Breljak, Davorka; Karaica, Dean; Sabolić, Ivan
Sodium-glucose cotransporters: new targets of cancer therapy? // Arhiv za higijenu rada i toksikologiju, 69 (2018), 4; 278-284 doi:10.2478/aiht-2018-69-3204 (međunarodna recenzija, pregledni rad, znanstveni)
Vrhovac Madunić, I., Madunić, J., Breljak, D., Karaica, D. & Sabolić, I. (2018) Sodium-glucose cotransporters: new targets of cancer therapy?. Arhiv za higijenu rada i toksikologiju, 69 (4), 278-284 doi:10.2478/aiht-2018-69-3204.
@article{article, year = {2018}, pages = {278-284}, DOI = {10.2478/aiht-2018-69-3204}, keywords = {brain cancer, Na+-dependent glucose transporters, pancreatic cancer, positron emission tomography, prostate cancer, SGLT inhibitors}, journal = {Arhiv za higijenu rada i toksikologiju}, doi = {10.2478/aiht-2018-69-3204}, volume = {69}, number = {4}, issn = {0004-1254}, title = {Sodium-glucose cotransporters: new targets of cancer therapy?}, keyword = {brain cancer, Na+-dependent glucose transporters, pancreatic cancer, positron emission tomography, prostate cancer, SGLT inhibitors} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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