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Pregled bibliografske jedinice broj: 972912

Role of Plasmapheresis in the Management of Acute Kidney Injury in Patients With Multiple Myeloma: Should We Abandon It?


Premužić, Vedran; Batinić, Josip; Rončević, Pavle; Bašić-Jukić, Nikolina; Nemet, Damir; Jelaković, Bojan
Role of Plasmapheresis in the Management of Acute Kidney Injury in Patients With Multiple Myeloma: Should We Abandon It? // Therapeutic apheresis and dialysis, 22 (2018), 1; 79-86 doi:10.1111/1744-9987.12606 (međunarodna recenzija, članak, znanstveni)


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Naslov
Role of Plasmapheresis in the Management of Acute Kidney Injury in Patients With Multiple Myeloma: Should We Abandon It?

Autori
Premužić, Vedran ; Batinić, Josip ; Rončević, Pavle ; Bašić-Jukić, Nikolina ; Nemet, Damir ; Jelaković, Bojan

Izvornik
Therapeutic apheresis and dialysis (1744-9979) 22 (2018), 1; 79-86

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Acute kidney injury ; Bortezomib ; Chemotherapy ; Free light chains ; Plasma exchange

Sažetak
The aim of the current study was to determine whether plasmapheresis in combination with chemotherapy could significantly remove free light chains (FLC) in multiple myeloma (MM) patients with acute kidney injury (AKI) and therefore improve renal recovery and patient survival. During the study period, 29 patients with MM and AKI presented to our unit and were treated with two different therapy modalities (plasmapheresis with chemotherapy or bortezomib). At the end of treatment, a significant decrease of FLCs was present in the group treated with plasmapheresis compared to the bortezomib group. Patients treated with plasmapheresis had similar survival compared to patients treated with bortezomib. There was a significantly higher decrease of FLCs and longer survival in patients treated with three or more plasmapheresis sessions than in patients treated with two plasmapheresis sessions. Plasmapheresis therapy still remains a useful and effective method in the treatment of AKI in MM patients. Plasmapheresis significantly reduces FLCs compared to bortezomib especially with higher number of plasma exchange sessions but it must be combined with other chemotherapy agents in order to prolong renal recovery and therefore patient survival.

Izvorni jezik
Engleski



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
Sveučilište Libertas

Citiraj ovu publikaciju

Premužić, Vedran; Batinić, Josip; Rončević, Pavle; Bašić-Jukić, Nikolina; Nemet, Damir; Jelaković, Bojan
Role of Plasmapheresis in the Management of Acute Kidney Injury in Patients With Multiple Myeloma: Should We Abandon It? // Therapeutic apheresis and dialysis, 22 (2018), 1; 79-86 doi:10.1111/1744-9987.12606 (međunarodna recenzija, članak, znanstveni)
Premužić, V., Batinić, J., Rončević, P., Bašić-Jukić, N., Nemet, D. & Jelaković, B. (2018) Role of Plasmapheresis in the Management of Acute Kidney Injury in Patients With Multiple Myeloma: Should We Abandon It?. Therapeutic apheresis and dialysis, 22 (1), 79-86 doi:10.1111/1744-9987.12606.
@article{article, year = {2018}, pages = {79-86}, DOI = {10.1111/1744-9987.12606}, keywords = {Acute kidney injury, Bortezomib, Chemotherapy, Free light chains, Plasma exchange}, journal = {Therapeutic apheresis and dialysis}, doi = {10.1111/1744-9987.12606}, volume = {22}, number = {1}, issn = {1744-9979}, title = {Role of Plasmapheresis in the Management of Acute Kidney Injury in Patients With Multiple Myeloma: Should We Abandon It?}, keyword = {Acute kidney injury, Bortezomib, Chemotherapy, Free light chains, Plasma exchange} }
@article{article, year = {2018}, pages = {79-86}, DOI = {10.1111/1744-9987.12606}, keywords = {Acute kidney injury, Bortezomib, Chemotherapy, Free light chains, Plasma exchange}, journal = {Therapeutic apheresis and dialysis}, doi = {10.1111/1744-9987.12606}, volume = {22}, number = {1}, issn = {1744-9979}, title = {Role of Plasmapheresis in the Management of Acute Kidney Injury in Patients With Multiple Myeloma: Should We Abandon It?}, keyword = {Acute kidney injury, Bortezomib, Chemotherapy, Free light chains, Plasma exchange} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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