engleski

Can the changes in immunohistochemical markers predict the occurence of recurrent carcinoma of the bladder?

The Multivariate adaptive regression splines analysis (MARS) was used to predict the total number of recurrences by 9 IHC markers (EGFR, HER2, HER3, e-cadherin, Ki67, MLH1, MSH2, MSH6 and PMS2), among 33 patient (24 male and 9 female), aged 57-87 years, with primary urinary bladder cancer and one to six recurrences. Data were divided as initial tumors, the first and later recurrences, and as tumors that will relapse in 9 or >9 months. All markers were semiquantitatively classified in four groups: “0” means no positive cells ; “1” ≤10% positive cells ; “2” 11%-30% positive cells ; and “3” 31%-100% positive cells. In predicting the total number of recurrences, the R2 value for all tumors was 0.423, for initial tumors 0.686, for the first recurrence 0.700, for later recurrences only 0.233. Key predictors for initial tumors were HER2 and MSH2, while for the first recurrence it was EGFR. For early recurrences, R2 was 0.474 with EGFR and HER3 as predictors, while for the late recurrences R2 was 0.640 due to EGFR and PMS2. The finding of e- cadherin was not found relevant by these MARS models. It is important that differences in predictive markers were found between the initial tumors and the first recurrences and between early and late recurrences, thus suggesting that tumor biology is different among these subgroups, regarding the total number of recurrences and Ki67 values.

urinary bladder carcinoma, recurrences, Lynch family markers, HER family markers

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