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Herpes Simplex Virus 1 Deregulation of Host MicroRNAs (CROSBI ID 257342)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Cokarić Brdovčak, Maja ; Zubković, Andreja ; Jurak, Igor Herpes Simplex Virus 1 Deregulation of Host MicroRNAs // Non-coding RNA, 4 (2018), 4; 36, 21. doi: 10.3390/ncrna4040036

Podaci o odgovornosti

Cokarić Brdovčak, Maja ; Zubković, Andreja ; Jurak, Igor

engleski

Herpes Simplex Virus 1 Deregulation of Host MicroRNAs

Viruses utilize microRNAs (miRNAs) in a vast variety of possible interactions and mechanisms, apparently far beyond the classical understanding of gene repression in humans. Likewise, herpes simplex virus 1 (HSV-1) expresses numerous miRNAs and deregulates the expression of host miRNAs. Several HSV-1 miRNAs are abundantly expressed in latency, some of which are encoded antisense to transcripts of important productive infection genes, indicating their roles in repressing the productive cycle and/or in maintenance/reactivation from latency. In addition, HSV-1 also exploits host miRNAs to advance its replication or repress its genes to facilitate latency. Here, we discuss what is known about the functional interplay between HSV- 1 and the host miRNA machinery, potential targets, and the molecular mechanisms leading to an efficient virus replication and spread.

HSV-1, miRNA

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Podaci o izdanju

4 (4)

2018.

36

21

objavljeno

2311-553X

10.3390/ncrna4040036

Povezanost rada

Biologija

Poveznice
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