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Blood pressure is associated with gama- glutamyltransferase and alkaline phosphatase in normoalbuminuric type 1 diabetic patients

It has been documented that markers of nonalcoholic fatty liver disease (NAFLD), γ- glutamyltransferase (GGT) and alkaline phosphatase (ALP), are associated with hypertension in patients with chronic kidney disease. The aim of this study was to explore the relationship of NAFLD markers, i.e. concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), ALP, GGT and bilirubin with blood pressure in type 1 diabetic patients with normal renal function. The study included 313 normoalbuminuric type 1 diabetic patients (estimated glomerular filtration rate (eGFR) >60 mL min-1 1.73m-2) with no medical history of liver, renal and cardiovascular diseases and before any interventions with statins, angiotensin- converting enzyme inhibitors or angiotensin II receptor blockers. GGT and ALP significantly correlated with systolic (r=0.13 and 0.12 ; p<0.05) and diastolic (r=0.11 and 0.16 ; p<0.05) blood pressure. Correlations of AST, ALT and bilirubin with systolic (r=0.06, 0.09 and 0.08) and diastolic (r=-0.05, 0.02 and 0.03) blood pressure were not statistically significant. Higher ALP and GGT can be an additional marker of hypertension in type 1 diabetic patients, indicating that these subjects are not only at a risk of hepatic disease, but also at a risk of coronary artery disease and progression of renal disease.

hypertension ; nonalcoholic fatty liver disease ; type 1 diabetes ; γ-glutamyltransferase ; alkaline phosphatase

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