engleski

What do we know about genetic susceptibility of thyroid and parathyroid function in general population?

Thyroid gland, through secretion of its hormones, regulates metabolism, growth and maturation of all human tissues. The parathyroid glands play a central role in the regulation of calcium metabolism. Circulating concentrations of thyroid and parathyroid hormones and antibodies are under prominent genetic control and influence of environmental factors. However, genetic variants underlying their function are not fully established. Majority of thyroid hormones and antibodies have been underrepresented in the genome-wide association studies (GWAS) or have not yet been investigated. There are ten published GWAS of thyroid stimulating hormone (TSH), four of free thyroxine (fT4), one of free triiodothyronine (fT3), and two of thyroid peroxidase antibody (TPOAb) in general population. First GWA study of parathyroid hormone (PTH) has been published recently. The overall goal of our project is to explore genetic and environmental factors underlying thyroid and parathyroid functions by studying the most comprehensive set of thyroid and parathyroid hormones/antibodies measured in the plasma of general population. The first objective of the project is genome-wide association analysis of seven thyroid and parathyroid hormones/antibodies (fT3, fT4, TSH, Tg, TPOAb, TgAb, PTH) in three independent cohorts of Split, Korcula and Vis (3.000 participants from “10.001 Dalmatian” project) followed by meta-analyses of genome-wide association results. Second and third objectives of our project are determination of gene-environment interaction of associated genetic variants with selected environmental factors, and determination of phenotype- phenotype correlation using the measurements of thyroid and parathyroid hormones/antibodies and selected environmental factors. Results of the project have a potential to improve the clinical practice by leading to novel preventive measures, inventing more effective treatments and creating personalized medicine based on individual genetic profiles. Results will also point to a specific set of risk and protective environmental factors important for thyroid and parathyroid function.

genetics ; thyroid ; parathyroid

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