Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians (CROSBI ID 257198)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Matana, Antonela ; Popović, Marijana ; Boutin, Thibaud ; Torlak, Vesela ; Brdar, Dubravka ; Gunjača, Ivana ; Kolčić, Ivana ; Boraska Perica, Vesna ; Punda, Ante ; Polašek, Ozren ; Hayward, Caroline, Barbalić, Maja ; Zemunik, Tatijana
engleski
Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians
Autoimmune thyroid diseases (AITD) are multifactorial endocrine diseases most frequently accompanied by Tg and TPO autoantibodies. Both antibodies have a higher prevalence in females and act under a strong genetic influence. To identify novel variants underlying thyroid antibody levels, we performed GWAS meta- analysis on the plasma levels of TgAb and TPOAb in three Croatian cohorts, as well as gender specific GWAS and a bivariate analysis. No significant association was detected with the level of TgAb and TPOAb in the meta- analysis of GWAS or bivariate results for all individuals. The bivariate analysis in females only revealed a genome-wide significant association for the locus near GRIN3A (rs4457391, P = 7.76 × 10−9). The same locus had borderline association with TPOAb levels in females (rs1935377, P = 8.58 × 10−8). In conclusion, we identified a novel gender specific locus associated with TgAb and TPOAb levels. Our findings provide a novel insight into genetic and gender differences associated with thyroid antibodies.
Genome-wide association study ; Meta-analysis ; Thyroid antibody ; Thyroglobulin ; Thyroid peroxidase ; Single nucleotide polymorphism
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Podaci o izdanju
111 (4)
2019.
737-743
objavljeno
0888-7543
1089-8646
10.1016/j.ygeno.2018.04.012.
Povezanost rada
Temeljne medicinske znanosti