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Pregled bibliografske jedinice broj: 971230

Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians


Matana, Antonela; Popović, Marijana; Boutin, Thibaud; Torlak, Vesela; Brdar, Dubravka; Gunjača, Ivana; Kolčić, Ivana; Boraska Perica, Vesna; Punda, Ante; Polašek, Ozren et al.
Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians // Genomics, / (2018), -. doi:10.1016/j.ygeno.2018.04.012. (međunarodna recenzija, članak, znanstveni)


Naslov
Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians

Autori
Matana, Antonela ; Popović, Marijana ; Boutin, Thibaud ; Torlak, Vesela ; Brdar, Dubravka ; Gunjača, Ivana ; Kolčić, Ivana ; Boraska Perica, Vesna ; Punda, Ante ; Polašek, Ozren ; Hayward, Caroline, Barbalić, Maja ; Zemunik, Tatijana

Izvornik
Genomics (0888-7543) (2018); 0

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Genome-wide association study ; Meta-analysis ; Thyroid antibody ; Thyroglobulin ; Thyroid peroxidase ; Single nucleotide polymorphism

Sažetak
Autoimmune thyroid diseases (AITD) are multifactorial endocrine diseases most frequently accompanied by Tg and TPO autoantibodies. Both antibodies have a higher prevalence in females and act under a strong genetic influence. To identify novel variants underlying thyroid antibody levels, we performed GWAS meta- analysis on the plasma levels of TgAb and TPOAb in three Croatian cohorts, as well as gender specific GWAS and a bivariate analysis. No significant association was detected with the level of TgAb and TPOAb in the meta- analysis of GWAS or bivariate results for all individuals. The bivariate analysis in females only revealed a genome-wide significant association for the locus near GRIN3A (rs4457391, P = 7.76 × 10−9). The same locus had borderline association with TPOAb levels in females (rs1935377, P = 8.58 × 10−8). In conclusion, we identified a novel gender specific locus associated with TgAb and TPOAb levels. Our findings provide a novel insight into genetic and gender differences associated with thyroid antibodies.

Izvorni jezik
Engleski

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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