Characterisation of the integrin αV-dependent adhesome in MDA-MB-435S melanoma cells (CROSBI ID 669853)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Paradžik, Mladen ; Humphries ; Jonathan D., Nestić, Davor ; Majhen, Dragomira ; Dekanić, Ana ; Stojanović, Nikolina ; Sedda, Delphine ; Weber, Igor ; Humphries, Martin J. ; Ambriović-Ristov, Andreja
engleski
Characterisation of the integrin αV-dependent adhesome in MDA-MB-435S melanoma cells
Integrins are heterodimeric glycoproteins consisted of α and β subunits that binds cells to extracellular matrix proteins. Upon integrin clustering, proteins are recruited to form multimolecular integrin adhesion complexes (IACs) that facilitate the linkage between integrins and the actin cytoskeleton and to permit bidirectional signalling. The αv integrin is expressed in most tumour cells where it regulates a diverse array of cellular functions. The aim of our work was to assess changes in IAC composition in melanoma cell line MDA-MB-435S in order to better understand beneficial effects of integrin αv knockdown in melanoma therapy.
breast cancer ; melanoma ; integrins ; adhesome
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Podaci o prilogu
8-8.
2018.
objavljeno
Podaci o matičnoj publikaciji
A COST Action CA15214 WG1-WG2-WG3-WG4 Networking Meeting " Mechanobiology of cells and tissues"
Andjus, Pavle ; Ambriović-Ristov, Andreja ; Travasso, Rui ; Saraiva, Nuno ; Liović, Mirjana
Ljubljana:
Podaci o skupu
A COST Action CA15214 Networking Meeting "Mechanobiology of cells and tissues in health and disease"
predavanje
08.11.2018-09.11.2018
Ljubljana, Slovenija
