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Pregled bibliografske jedinice broj: 970659

Characterisation of integrin αV-dependent adhesome in melanoma cell line MDA-MB-435S


Paradžik, Mladen; Humphries, Jonathan D.; Nestić, Davor; Majhen, Dragomira; Dekanić, Ana; Stojanović, Nikolina; Sedda, Delphine; Samaržija, Ivana; Weber, Igor; Humphries, Martin J.; Ambriović-Ristov, Andreja
Characterisation of integrin αV-dependent adhesome in melanoma cell line MDA-MB-435S // Signal Transduction in Cancer- Abstracts / Defilippi, Paola ; Lanzetti, Letizia ; Belletti, Barbara (ur.).
Torino: Associazione di Biologia Cellulare e del Differenziamento, 2018. str. 5-5 (predavanje, međunarodna recenzija, sažetak, znanstveni)


Naslov
Characterisation of integrin αV-dependent adhesome in melanoma cell line MDA-MB-435S

Autori
Paradžik, Mladen ; Humphries, Jonathan D. ; Nestić, Davor ; Majhen, Dragomira ; Dekanić, Ana ; Stojanović, Nikolina ; Sedda, Delphine ; Samaržija, Ivana ; Weber, Igor ; Humphries, Martin J. ; Ambriović-Ristov, Andreja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Signal Transduction in Cancer- Abstracts / Defilippi, Paola ; Lanzetti, Letizia ; Belletti, Barbara - Torino : Associazione di Biologia Cellulare e del Differenziamento, 2018, 5-5

Skup
Associazione di Biologia Cellulare e del Differenziamento Meeting- Signal Transduction in Cancer

Mjesto i datum
Torino, Italija, 22-24.11.2018

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Breast cancer, melanoma, integrins, adhesome

Sažetak
Integrins are heterodimeric glycoproteins that bind cells to extracellular matrix proteins. Upon integrin clustering, multimolecular integrin adhesion complexes (IACs) are formed, facilitating the linkage between integrins and the actin cytoskeleton and permitting bidirectional signalling. The aim of this work was to assess αV-dependent changes in IAC composition in MDA-MB-435S melanoma cells in order to better understand the alteration of sensitivity to antitumor drugs and migration, observed upon transient transfection with integrin αV siRNA.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-2465 - MOLEKULARNI MEHANIZMI POVEĆANJA OSJETLJIVOSTI NA PROTUTUMORSKE LIJEKOVE STANICA KARCINOMA DOJKE I MELANOMA ČOVJEKA UTIŠAVANJEM INTEGRINA (Andreja Ristov, )

Ustanove
Institut "Ruđer Bošković", Zagreb