Characterisation of integrin αV-dependent adhesome in melanoma cell line MDA-MB-435S (CROSBI ID 669842)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Paradžik, Mladen ; Humphries, Jonathan D. ; Nestić, Davor ; Majhen, Dragomira ; Dekanić, Ana ; Stojanović, Nikolina ; Sedda, Delphine ; Samaržija, Ivana ; Weber, Igor ; Humphries, Martin J. ; Ambriović-Ristov, Andreja
engleski
Characterisation of integrin αV-dependent adhesome in melanoma cell line MDA-MB-435S
Integrins are heterodimeric glycoproteins that bind cells to extracellular matrix proteins. Upon integrin clustering, multimolecular integrin adhesion complexes (IACs) are formed, facilitating the linkage between integrins and the actin cytoskeleton and permitting bidirectional signalling. The aim of this work was to assess αV-dependent changes in IAC composition in MDA-MB-435S melanoma cells in order to better understand the alteration of sensitivity to antitumor drugs and migration, observed upon transient transfection with integrin αV siRNA.
breast cancer ; melanoma ; integrins ; adhesome
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Podaci o prilogu
5-5.
2018.
objavljeno
Podaci o matičnoj publikaciji
Signal Transduction in Cancer : Abstract book
Defilippi, Paola ; Lanzetti, Letizia ; Belletti, Barbara
Torino: Associazione di Biologia Cellulare e del Differenziamento
Podaci o skupu
ABCD Meeting Signal Transduction in Cancer
predavanje
22.11.2018-24.11.2018
Torino, Italija
