engleski

How does bacterial pathogen Helicobacter pylori control responses to cellular stress?

H. pylori infection causes damage of DNA in host cells, triggering the DNA damage response. Inhibition of DNA damage repair and p53 activity by H. pylori may be the links in the same chain of bacterial adaptive responses directed to prevent the host response to cellular stress. Unfortunately, this may have severe consequences for the host, increasing the risk of pathological changes and tumor development. Future studies of bacterial modulation of host stress responses will lead to better understanding of bacterial pathogenesis and help to identify potential targets in the prevention of cancers associated with bacterial infections.

Gastric cancer ; Helicobacter pylori ; p53

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