Napredna pretraga

Pregled bibliografske jedinice broj: 969663

Effect of Notch and PARP Pathways’ Inhibition in Leukemic Cells


Horvat, Luka; Antica, Mariastefania; Matulić, Maja
Effect of Notch and PARP Pathways’ Inhibition in Leukemic Cells // Cells, 7 (2018), 6; 58-70 doi:10.3390/cells7060058 (međunarodna recenzija, članak, znanstveni)


Naslov
Effect of Notch and PARP Pathways’ Inhibition in Leukemic Cells

Autori
Horvat, Luka ; Antica, Mariastefania ; Matulić, Maja

Izvornik
Cells (2073-4409) 7 (2018), 6; 58-70

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
B and T leukemia cell line ; Notch ; PARP1 ; Ikaros ; Jagged ; gene expression

Sažetak
Differentiation of blood cells is one of the most complex processes in the body. It is regulated by the action of transcription factors in time and space which creates a specific signaling network. In the hematopoietic signaling system, Notch is one of the main regulators of lymphocyte development. The aim of this study was to get insight into the regulation of Notch signalization and the influence of poly(ADP-ribose)polymerase (PARP) activity on this process in three leukemia cell lines obtained from B and T cells. PARP1 is an enzyme involved in posttranslational protein modification and chromatin structure changes. B and T leukemia cells were treated with Notch and PARP inhibitors, alone or in combination, for a prolonged period. The cells did not show cell proliferation arrest or apoptosis. Analysis of gene and protein expression set involved in Notch and PARP pathways revealed increase in JAGGED1 expression after PARP1 inhibition in B cell lines and changes in Ikaros family members in both B and T cell lines after γ-secretase inhibition. These data indicate that Notch and PARP inhibition, although not inducing differentiation in leukemia cells, induce changes in signaling circuits and chromatin modelling factors.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekt / tema
098-0982913-2332 - Molekularne interakcije u diferencijaciji limfocita (Mariastefania Antica, )
119-0000000-3172 - Poli(ADPribozilacija, starenje i plazminogenska aktivacija u tumorskim stanicama (Maja Matulić, )
HRZZ-IP-2013-11-7140 - Notch u diferencijaciji hematopoetskih stanica matica i u razvoju leukemija (Mariastefania Antica, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • CA Search (Chemical Abstracts)
  • EMBASE (Excerpta Medica)
  • AGORA
  • DOAJ
  • Genamics JournalSeekexternal link
  • JCR/Science Edition
  • Julkaisufoorumi Publication Forum external link
  • OARE


Citati