Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 967828

Purine nucleoside phosphorylases: understanding enzyme mechanism and allosteric pathways


Štefanić, Zoran; Luić, Marija
Purine nucleoside phosphorylases: understanding enzyme mechanism and allosteric pathways // The Twenty-Sixth Croatian-Slovenian Crystallographic Meeting: Book of Abstracts / Cetina, Mario ; Golobič, Amalija ; Jurić, Marijana ; Klaser, Teodoro ; Lozinšek, Matic ; Pevec, Andrej ; Počkaj, Marta ; Zema, Michele (ur.).
Zagreb, 2018. str. 5-5 (plenarno, nije recenziran, sažetak, ostalo)


CROSBI ID: 967828 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Purine nucleoside phosphorylases: understanding enzyme mechanism and allosteric pathways

Autori
Štefanić, Zoran ; Luić, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
The Twenty-Sixth Croatian-Slovenian Crystallographic Meeting: Book of Abstracts / Cetina, Mario ; Golobič, Amalija ; Jurić, Marijana ; Klaser, Teodoro ; Lozinšek, Matic ; Pevec, Andrej ; Počkaj, Marta ; Zema, Michele - Zagreb, 2018, 5-5

Skup
26th Croatian-Slovenian Crystallographic Meeting

Mjesto i datum
Poreč, Hrvatska, 13-17.06.2018

Vrsta sudjelovanja
Plenarno

Vrsta recenzije
Nije recenziran

Ključne riječi
Purine nucleoside phosphorylase ; allostery

Sažetak
Purine nucleoside phosphorylases (PNPs) have been the subject of our scientific interest for a number of years [1]. Despite much progress that has been made in understanding the catalytic mechanism of PNPs, there are still many pieces of the puzzle to be discovered. Recently, we have determined the first crystal structure of PNP from Helicobacter pylori (HpPNP) which is an essential enzyme of its purine salvage pathway [2]. HpPNP seems to posses some unusual features that distinguish it from other PNPs. Moreover, its crucial role in the purine salvage pathway of this serious human pathogen, makes it a very promising drug target [3]. As more and more crystal structures of this enzyme become available, the evidence grows of intricate communication, maybe even allosterically regulated, between the active sites [4]. Perhaps related to this, the number of possible configurations of open and closed active sites in crystal structures is also growing, and HpPNP is displaying even some previously unobserved ones [4]. Various approaches to tackle these open questions, that have crystal structures as a starting point, will be discussed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Projekti:
HRZZ-IP-2013-11-7423 - Enzimi purinskog reciklirajućeg ciklusa iz Helicobacter pylori i Escherichie coli (PSPE) (Luić, Marija, HRZZ - 2013-11) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Marija Luić (autor)

Avatar Url Zoran Štefanić (autor)

Citiraj ovu publikaciju:

Štefanić, Zoran; Luić, Marija
Purine nucleoside phosphorylases: understanding enzyme mechanism and allosteric pathways // The Twenty-Sixth Croatian-Slovenian Crystallographic Meeting: Book of Abstracts / Cetina, Mario ; Golobič, Amalija ; Jurić, Marijana ; Klaser, Teodoro ; Lozinšek, Matic ; Pevec, Andrej ; Počkaj, Marta ; Zema, Michele (ur.).
Zagreb, 2018. str. 5-5 (plenarno, nije recenziran, sažetak, ostalo)
Štefanić, Z. & Luić, M. (2018) Purine nucleoside phosphorylases: understanding enzyme mechanism and allosteric pathways. U: Cetina, M., Golobič, A., Jurić, M., Klaser, T., Lozinšek, M., Pevec, A., Počkaj, M. & Zema, M. (ur.)The Twenty-Sixth Croatian-Slovenian Crystallographic Meeting: Book of Abstracts.
@article{article, year = {2018}, pages = {5-5}, keywords = {Purine nucleoside phosphorylase, allostery}, title = {Purine nucleoside phosphorylases: understanding enzyme mechanism and allosteric pathways}, keyword = {Purine nucleoside phosphorylase, allostery}, publisherplace = {Pore\v{c}, Hrvatska} }
@article{article, year = {2018}, pages = {5-5}, keywords = {Purine nucleoside phosphorylase, allostery}, title = {Purine nucleoside phosphorylases: understanding enzyme mechanism and allosteric pathways}, keyword = {Purine nucleoside phosphorylase, allostery}, publisherplace = {Pore\v{c}, Hrvatska} }




Contrast
Increase Font
Decrease Font
Dyslexic Font