Rapid endosomal recycling (CROSBI ID 62243)
Prilog u knjizi | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Mahmutefendić, Hana ; Blagojević Zagorac, Gordana ; Maćešić, Senka ; Lučin, Pero
engleski
Rapid endosomal recycling
Peripheral membrane proteins are endocytosed by constitutive processes of membrane invaginations, followed by internalization driven by diverse endocytic machinery available at the cell surface. It is believed that after endocytic uptake, cargo proteins proceed either through the endosomal recycling circuit of the cell or travel toward late endosomes for degradation. In this chapter, we analyzed trafficking of seven cargo molecules (transferrin receptor, fully conformed MHC-I, non-conformed MHC-I, cholera-toxin B subunit, CD44, ICAM1, and G-protein-coupled receptor Rae-1) known to use the distinct endocytic route. For that purpose, we developed the software for multicompartment analysis of intracellular trafficking. We demonstrate that all endocytosed molecules are rapidly recycled and propose that the rapid recycling is a constitutive process that should be considered in the analysis of intracellular trafficking of peripheral membrane proteins.
rapid endosomal recycling ; clathrin-independent cargo ; endosomal recycling ; endosomal trafficking ; kinetic modeling of endosomal trafficking ; transferrin receptor
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Podaci o prilogu
83-104.
objavljeno
10.5772/intechopen.75685
Podaci o knjizi
Peripheral membrane proteins
Shihori, Tanabe
London : Delhi: IntechOpen
2018.
978-1-78923-513-5