engleski

The Significance of Ki-67 in Head and Neck Cancers: Review Article

Widely accepted prognostic factors like lymph node status, tumor size and cell differentiation sometimes are not useful in oral cancer diagnostics and prognosis. Therefore, study of tumor heterogeneity which involves also molecular markers might be useful in order to explain mechanisms of appearance and recurrences of oral squamous cell cancer. The aim of the present study was to search published literature in the last 25 years regarding the role of Ki-67 in the head and neck cancers. Thirty seven articles were included and results showed that Ki-67 is not reliable prognostic marker for oral squamous cell carcinoma because of contradictory results of the available studies.

Ki-67 ; head and neck cancer ; molecular marker ; prognosis

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