engleski

Subcellular localization and expression of NME6, a member of the NME/NM23/NDPK family, in human tumour cells

Nucleoside diphosphate kinases (NDPKs) catalyse the exchange of the terminal phosphate from trinucleotides to dinucleotides through a high- energy phosphohistidine intermedier. They are encoded by NME genes and have been found, with a few exceptions, in all living beings. Besides their well-known function as key regulators of the cellular nucleotide homeostasis, they have been appointed numerous additional biochemical and biological functions. The family consists of ten members. NME1- NME4, have been extensively studied, especially NME1 in the context of metastasis formation. The NME1-NME4 are highly homologous among themselves and they all possess the NDP kinase activity in their hexameric form. The information on NME5-NME9 members is rather scarce but it is known that they display a lower level of mutual homology and apparently do not possess the NDP kinase activity. Their multimeric structure has not yet been revealed. The goal of our recent studies is revealing the subcellular localization, structure and function of NME6.

Nme6 protein ; localization

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