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izvor podataka: crosbi

Expression profiles of P53/P73 isoforms in human melanoma cell lines (CROSBI ID 668617)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Slade, Neda ; Hanžić, Nikolina ; Radić, Martina ; Ozretić, Petar ; Petrović, Lidija ; Jazvinšćak Jembrek, Maja Expression profiles of P53/P73 isoforms in human melanoma cell lines // ESMO Open / Berns, Anton (ur.). 2018. str. A289-A289 doi: 10.1136/esmoopen-2018-EACR25.681

Podaci o odgovornosti

Slade, Neda ; Hanžić, Nikolina ; Radić, Martina ; Ozretić, Petar ; Petrović, Lidija ; Jazvinšćak Jembrek, Maja

engleski

Expression profiles of P53/P73 isoforms in human melanoma cell lines

TP53 is the most frequently mutated gene in human cancer. However, in metastatic melanoma mutations of TP53 occur infrequently and p53 fails to function as a tumour suppressor. The altered expression of p53 family members, including p53/p73 isoforms, as well as of the interactions among them could affect the normal function of p53. Furthermore, somatic BRAF mutations have been found in 37%–50% of all melanomas, of which almost 90% harbour the activating V600E mutation. Although the initial response to BRAF inhibitors is highly effective, the resistant clones frequently develop, and, in treated patients disease progression is observed within 6 to 8 months. To address this, a better understanding of the genetic basis of melanoma initiation and progression is needed.

p53 protein ; metastatic melanoma ; BRAF inhibitors

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Podaci o prilogu

A289-A289.

2018.

nije evidentirano

objavljeno

10.1136/esmoopen-2018-EACR25.681

Podaci o matičnoj publikaciji

ESMO Open

Berns, Anton

London : Delhi: European Society for Medical Oncology

2059-7029

Podaci o skupu

25th Biennial Congress of the European Association for Cancer Research (EACR25)

poster

30.06.2018-03.07.2018

Amsterdam, Nizozemska

Povezanost rada

Temeljne medicinske znanosti

Poveznice