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Pregled bibliografske jedinice broj: 966184

Expression profiles of P53/P73 isoforms in human melanoma cell lines


Slade, Neda; Hanžić, Nikolina; Radić, Martina; Ozretić, Petar; Petrović, Lidija; Jazvinšćak Jembrek, Maja
Expression profiles of P53/P73 isoforms in human melanoma cell lines // Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, in ESMO Open, Volume 3, Supplement 2 / Berns, Anton (ur.).
London: European Society for Medical Oncology, 2018. str. A289-A289 doi:10.1136/esmoopen-2018-EACR25.681 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 966184 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Expression profiles of P53/P73 isoforms in human melanoma cell lines

Autori
Slade, Neda ; Hanžić, Nikolina ; Radić, Martina ; Ozretić, Petar ; Petrović, Lidija ; Jazvinšćak Jembrek, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, in ESMO Open, Volume 3, Supplement 2 / Berns, Anton - London : European Society for Medical Oncology, 2018, A289-A289

Skup
EACR25: 25th Biennial Congress of the European Association for Cancer Research

Mjesto i datum
Amsterdam, Nizozemska, 30.06.-03.07.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
p53 protein ; metastatic melanoma ; BRAF inhibitors

Sažetak
TP53 is the most frequently mutated gene in human cancer. However, in metastatic melanoma mutations of TP53 occur infrequently and p53 fails to function as a tumour suppressor. The altered expression of p53 family members, including p53/p73 isoforms, as well as of the interactions among them could affect the normal function of p53. Furthermore, somatic BRAF mutations have been found in 37%–50% of all melanomas, of which almost 90% harbour the activating V600E mutation. Although the initial response to BRAF inhibitors is highly effective, the resistant clones frequently develop, and, in treated patients disease progression is observed within 6 to 8 months. To address this, a better understanding of the genetic basis of melanoma initiation and progression is needed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
IP-2013-11-1615 - Otkrivanje novih proteinskih interakcija kao podloga za nove pristupe liječenju melanoma čovjeka (ProNetMel) (Slade, Neda, HRZZ - 2013-11) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Poveznice na cjeloviti tekst rada:

doi www.esmoopen.com doi.org

Citiraj ovu publikaciju:

Slade, Neda; Hanžić, Nikolina; Radić, Martina; Ozretić, Petar; Petrović, Lidija; Jazvinšćak Jembrek, Maja
Expression profiles of P53/P73 isoforms in human melanoma cell lines // Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, in ESMO Open, Volume 3, Supplement 2 / Berns, Anton (ur.).
London: European Society for Medical Oncology, 2018. str. A289-A289 doi:10.1136/esmoopen-2018-EACR25.681 (poster, međunarodna recenzija, sažetak, znanstveni)
Slade, N., Hanžić, N., Radić, M., Ozretić, P., Petrović, L. & Jazvinšćak Jembrek, M. (2018) Expression profiles of P53/P73 isoforms in human melanoma cell lines. U: Berns, A. (ur.)Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, in ESMO Open, Volume 3, Supplement 2 doi:10.1136/esmoopen-2018-EACR25.681.
@article{article, author = {Slade, Neda and Han\v{z}i\'{c}, Nikolina and Radi\'{c}, Martina and Ozreti\'{c}, Petar and Petrovi\'{c}, Lidija and Jazvin\v{s}\'{c}ak Jembrek, Maja}, editor = {Berns, A.}, year = {2018}, pages = {A289-A289}, DOI = {10.1136/esmoopen-2018-EACR25.681}, keywords = {p53 protein, metastatic melanoma, BRAF inhibitors}, doi = {10.1136/esmoopen-2018-EACR25.681}, title = {Expression profiles of P53/P73 isoforms in human melanoma cell lines}, keyword = {p53 protein, metastatic melanoma, BRAF inhibitors}, publisher = {European Society for Medical Oncology}, publisherplace = {Amsterdam, Nizozemska} }
@article{article, author = {Slade, Neda and Han\v{z}i\'{c}, Nikolina and Radi\'{c}, Martina and Ozreti\'{c}, Petar and Petrovi\'{c}, Lidija and Jazvin\v{s}\'{c}ak Jembrek, Maja}, editor = {Berns, A.}, year = {2018}, pages = {A289-A289}, DOI = {10.1136/esmoopen-2018-EACR25.681}, keywords = {p53 protein, metastatic melanoma, BRAF inhibitors}, doi = {10.1136/esmoopen-2018-EACR25.681}, title = {Expression profiles of P53/P73 isoforms in human melanoma cell lines}, keyword = {p53 protein, metastatic melanoma, BRAF inhibitors}, publisher = {European Society for Medical Oncology}, publisherplace = {Amsterdam, Nizozemska} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Emerging Sources Citation Index (ESCI)


Citati:





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