Expression profiles of P53/P73 isoforms in human melanoma cell lines (CROSBI ID 668617)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Slade, Neda ; Hanžić, Nikolina ; Radić, Martina ; Ozretić, Petar ; Petrović, Lidija ; Jazvinšćak Jembrek, Maja
engleski
Expression profiles of P53/P73 isoforms in human melanoma cell lines
TP53 is the most frequently mutated gene in human cancer. However, in metastatic melanoma mutations of TP53 occur infrequently and p53 fails to function as a tumour suppressor. The altered expression of p53 family members, including p53/p73 isoforms, as well as of the interactions among them could affect the normal function of p53. Furthermore, somatic BRAF mutations have been found in 37%–50% of all melanomas, of which almost 90% harbour the activating V600E mutation. Although the initial response to BRAF inhibitors is highly effective, the resistant clones frequently develop, and, in treated patients disease progression is observed within 6 to 8 months. To address this, a better understanding of the genetic basis of melanoma initiation and progression is needed.
p53 protein ; metastatic melanoma ; BRAF inhibitors
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Podaci o prilogu
A289-A289.
2018.
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objavljeno
10.1136/esmoopen-2018-EACR25.681
Podaci o matičnoj publikaciji
ESMO Open
Berns, Anton
London : Delhi: European Society for Medical Oncology
2059-7029
Podaci o skupu
25th Biennial Congress of the European Association for Cancer Research (EACR25)
poster
30.06.2018-03.07.2018
Amsterdam, Nizozemska
Povezanost rada
Temeljne medicinske znanosti